ALDH3B1 and KRTAP3-3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALDH3B1	KRTAP3-3
Description		aldehyde dehydrogenase 3 family member B1	keratin associated protein 3-3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Membrane Vesicle Specific Granule Membrane Extracellular Exosome	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	3-chloroallyl Aldehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Benzaldehyde Dehydrogenase (NADP+) Activity Benzaldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase (NADP+) Activity Long-chain Fatty Aldehyde Dehydrogenase (NAD+) Activity Medium-chain Fatty Aldehyde Dehydrogenase (NAD+) Activity	Structural Molecule Activity Protein Binding
	Biological Process	Alcohol Metabolic Process Ethanol Catabolic Process Aldehyde Metabolic Process Lipid Metabolic Process Response To Oxidative Stress Sphingolipid Catabolic Process Cellular Response To Oxidative Stress Aldehyde Catabolic Process
Pathways		Neutrophil degranulation Sphingolipid catabolism	Keratinization
Drugs		NADH
Diseases
GWAS		Serum uric acid levels ( 32514006)
Interacting Genes		18 interacting genes: CYSRT1 HSD17B10 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP3-3 KRTAP4-2 KRTAP5-9 MID2 NOTCH2NLA	78 interacting genes: ALDH3B1 ANAPC11 ARID5A ATG9A BEX2 CELF5 CERCAM CIMAP1B CTSZ CYSRT1 DCANP1 DCDC2B DMRT3 DOCK2 ERMAP FADS6 FAM168A FARS2 FOXC2 FOXH1 FOXP3 GNE GPS2 GSTP1 GUCD1 HOXA1 HR HYPK KLHL38 KRT83 KRTAP10-1 KRTAP12-3 KRTAP12-4 KRTAP13-2 KRTAP15-1 KRTAP19-2 KRTAP19-7 KRTAP4-11 KRTAP4-2 KRTAP5-6 KRTAP6-2 KRTAP9-3 KRTAP9-8 LASP1 LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LONRF1 LRRN4 MGAT5B MRPL23 MXD3 NR1D2 NTAQ1 NUFIP2 OLIG3 OTX1 P2RY6 PATZ1 PHLDA1 PITX1 PITX2 PLSCR3 PLSCR4 PRKAB2 PVR SHISA6 SMARCC1 SSC4D TNFRSF12A VENTX VGLL3 YPEL3 ZNF503
Entrez ID		221	85293
HPRD ID		02716	13939
Ensembl ID		ENSG00000006534	ENSG00000212899
Uniprot IDs		A0A087X2D4 P43353	Q9BYR6
PDB IDs
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Epidermis Development Structural Molecule Activity Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Cholate 7-alpha-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Brexanolone Metabolic Process Mitochondrial Ribonuclease P Complex Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing Mitochondrial TRNA Methylation Mitochondrial RNA 5'-end Processing	Intermediate Filament Keratinization Keratin Filament Epidermis Development Protein Binding Tissue Development Hair Cycle Phospholipid Scramblase Activity Plasma Membrane Phospholipid Scrambling Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Chromatin
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