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RAPGEF5 and TMEM253
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
RAPGEF5
TMEM253
Gene Name
Rap guanine nucleotide exchange factor (GEF) 5
transmembrane protein 253
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Integral Component Of Membrane
Molecular Function
Ras Guanyl-nucleotide Exchange Factor Activity
Rap Guanyl-nucleotide Exchange Factor Activity
GTP-dependent Protein Binding
Biological Process
Small GTPase Mediated Signal Transduction
Nervous System Development
Positive Regulation Of Ras GTPase Activity
Positive Regulation Of Rap GTPase Activity
Pathways
Drugs
Diseases
GWAS
Dialysis-related mortality (
21546767
)
Thyroid stimulating hormone (
17903292
)
Protein-Protein Interactions
7 interactors:
MRAS
PLAC9
RAP1A
RAP2A
RAP2B
TMEM253
VANGL1
2 interactors:
RAPGEF5
TUBA1B
Entrez ID
9771
643382
HPRD ID
15208
Ensembl ID
ENSG00000136237
ENSG00000232070
Uniprot IDs
A8MQ07
Q5JPD2
Q92565
P0C7T8
PDB IDs
1WGY
Enriched GO Terms of Interacting Partners
?
Rap Protein Signal Transduction
Ras Protein Signal Transduction
Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Autophosphorylation
Regulation Of Protein Autophosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Platelet Activation
Negative Regulation Of Cell Migration
Negative Regulation Of Cell Motility
Regulation Of Protein Phosphorylation
Negative Regulation Of Cellular Component Movement
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Locomotion
Positive Regulation Of Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Vasculogenesis
Regulation Of Neuron Projection Development
Nerve Growth Factor Signaling Pathway
Blood Coagulation
Hemostasis
Microvillus Assembly
Negative Regulation Of Synaptic Vesicle Exocytosis
Microvillus Organization
Regulation Of Vasculogenesis
Positive Regulation Of Rap GTPase Activity
Regulation Of Cell Projection Organization
Negative Regulation Of Neurotransmitter Secretion
Regulation Of Rap GTPase Activity
Negative Regulation Of Neurotransmitter Transport
Regulation Of Cellular Protein Metabolic Process
Regulation Of Neuron Differentiation
Regulation Of Rap Protein Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Body Fluid Levels
Regulation Of Cell Migration
Establishment Of Endothelial Barrier
Wound Healing
Actin Cytoskeleton Organization
Regulation Of MAPK Cascade
Regulation Of Cell Motility
Multicellular Organismal Development
Regulation Of Protein Metabolic Process
Regulation Of Synaptic Vesicle Exocytosis
Actin Filament-based Process
Regulation Of Locomotion
Cell Activation
Positive Regulation Of Rap GTPase Activity
Regulation Of Rap GTPase Activity
Regulation Of Rap Protein Signal Transduction
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Tagcloud (Difference)
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Tagcloud (Intersection)
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