RAPGEF5 and TMEM253

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RAPGEF5	TMEM253
Description		Rap guanine nucleotide exchange factor 5	transmembrane protein 253
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body	Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding
	Biological Process	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development
Pathways
Drugs
Diseases
GWAS		Asthma ( 34103634) Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Gamma glutamyl transferase levels ( 33339817) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)
Interacting Genes		7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	2 interacting genes: RAPGEF5 TUBA1B
Entrez ID		9771	643382
HPRD ID		15208
Ensembl ID		ENSG00000136237	ENSG00000232070
Uniprot IDs		A0A0S2Z561 A8MQ07 Q92565	P0C7T8
PDB IDs		1WGY
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding Bounding Membrane Of Organelle Establishment Of Endothelial Barrier Endothelial Cell Development Intracellular Signaling Cassette Specific Granule Membrane Integrin Alphav-beta8 Complex Response To Antineoplastic Agent Recycling Endosome Membrane Epithelial Cell Development Langerhans Cell Differentiation Recycling Endosome Extracellular Matrix Protein Binding Positive Regulation Of Microvillus Assembly Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Cytoplasmic Vesicle Membrane
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