RAPGEF5 and MRAS

Number of citations of the paper that reports this interaction (PMID 10934204)
24

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		RAPGEF5	MRAS
Gene Name		Rap guanine nucleotide exchange factor (GEF) 5	muscle RAS oncogene homolog
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Ras Guanyl-nucleotide Exchange Factor Activity Rap Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding	GTPase Activity GTP Binding GTP-dependent Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Nervous System Development Positive Regulation Of Ras GTPase Activity Positive Regulation Of Rap GTPase Activity	Ras Protein Signal Transduction Multicellular Organismal Development Muscle Organ Development Actin Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Thyroid stimulating hormone ( 17903292)	Coronary heart disease ( 19198612 21378990)
Protein-Protein Interactions		7 interactors: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1	10 interactors: BRAF MLLT4 PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 TCEB1
Entrez ID		9771	22808
HPRD ID		15208	06662
Ensembl ID		ENSG00000136237	ENSG00000158186
Uniprot IDs		A8MQ07 Q5JPD2 Q92565	O14807 Q6FGP0 Q8WVM9
PDB IDs		1WGY
Enriched GO Terms of Interacting Partners?		Rap Protein Signal Transduction Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Autophosphorylation Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Platelet Activation Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of Protein Phosphorylation Negative Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Vasculogenesis Regulation Of Neuron Projection Development Nerve Growth Factor Signaling Pathway Blood Coagulation Hemostasis Microvillus Assembly Negative Regulation Of Synaptic Vesicle Exocytosis Microvillus Organization Regulation Of Vasculogenesis Positive Regulation Of Rap GTPase Activity Regulation Of Cell Projection Organization Negative Regulation Of Neurotransmitter Secretion Regulation Of Rap GTPase Activity Negative Regulation Of Neurotransmitter Transport Regulation Of Cellular Protein Metabolic Process Regulation Of Neuron Differentiation Regulation Of Rap Protein Signal Transduction Cellular Response To Nerve Growth Factor Stimulus Regulation Of Body Fluid Levels Regulation Of Cell Migration Establishment Of Endothelial Barrier Wound Healing Actin Cytoskeleton Organization Regulation Of MAPK Cascade Regulation Of Cell Motility Multicellular Organismal Development Regulation Of Protein Metabolic Process Regulation Of Synaptic Vesicle Exocytosis Actin Filament-based Process Regulation Of Locomotion Cell Activation	Positive Regulation Of Rap GTPase Activity Regulation Of Rap GTPase Activity Regulation Of Rap Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of GTPase Activity Regulation Of Peptidyl-serine Phosphorylation Signal Transduction Regulation Of Metabolic Process Signaling Cell Communication Response To Stimulus Regulation Of Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Growth Factor Stimulus Response To Growth Factor Ras Protein Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of GTPase Activity Activation Of MAPKK Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Somatic Stem Cell Maintenance Death-inducing Signaling Complex Assembly Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Ras GTPase Activity Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Hypomethylation Of CpG Island Response To Peptide Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Regulation Of Cellular Process
Tagcloud ?			acetylcholine anion antihypertensive assume bioavailability cuff cyclooxygenase deleterious deoxycorticosterone doca gavage hypertension hypertensive mesenteric myograph nad nak nakatpase ouabain reasonable relaxation rosta rostafuroxin salt sbp uninephrectomized wire wistar
Tagcloud (Difference) ?			acetylcholine anion antihypertensive assume bioavailability cuff cyclooxygenase deleterious deoxycorticosterone doca gavage hypertension hypertensive mesenteric myograph nad nak nakatpase ouabain reasonable relaxation rosta rostafuroxin salt sbp uninephrectomized wire wistar
Tagcloud (Intersection) ?