MAD2L1 and MAD2L1BP

Number of citations: 57 (PubMedID 12456649)
Data Source: HPRD (two hybrid, in vivo)

		MAD2L1	MAD2L1BP
Name		mitotic arrest deficient 2 like 1	MAD2L1 binding protein
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Mitotic Checkpoint Complex Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Spindle Cytoskeleton Nuclear Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Regulation Of Nuclear Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity	Regulation Of Exit From Mitosis Deactivation Of Mitotic Spindle Assembly Checkpoint
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	None
GWAS		Coronary artery disease ( 28714974 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) F-cell distribution in sickle cell anaemia ( 21326311 ) HIV-1 viral setpoint ( 22174851 ) Loneliness (multivariate analysis) ( 27629369 ) Myocardial infarction ( 33532862 ) Refractive error ( 32231278 )	Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		25 interacting genes: ADAM17 ANAPC2 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD	18 interacting genes: ANAPC4 CEP126 EEF1A1 HOMEZ IGSF21 KAT5 KRT15 LRIF1 MAD2L1 MAD2L2 NMI PLK1 PTN SETDB1 TP53 TRIP13 ZBTB14 ZNF202
Entrez ID		4085	9587
HPRD ID		03274	10065
Ensembl ID		ENSG00000164109	ENSG00000124688
Uniprot IDs		Q13257	Q15013
PDB IDs		1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ	2QYF 6F0X
GO Terms Enriched among Interactors		Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Separation Regulation Of Nuclear Division Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex Regulation Of Cell Cycle Process Regulation Of Meiotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Metaphase/anaphase Transition Of Cell Cycle Cell Division Regulation Of Reproductive Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Phase Transition Spindle Negative Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint PTB Domain Binding Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cell Cycle Meiotic Cell Cycle Phase Transition Zeta DNA Polymerase Complex Negative Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Growth	Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Chromosome Organization Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Chromosome Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Negative Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Double-strand Break Repair Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of Mitotic Nuclear Division Establishment Of Mitotic Spindle Orientation Negative Regulation Of Cell Cycle Process Microtubule Cytoskeleton Organization Involved In Mitosis Establishment Of Mitotic Spindle Localization Negative Regulation Of Double-strand Break Repair Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Establishment Of Spindle Orientation Regulation Of Nuclear Division Negative Regulation Of Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Recombination Chromosome Organization Establishment Of Spindle Localization Negative Regulation Of Cell Cycle Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus Negative Regulation Of Metabolic Process Negative Regulation Of Ubiquitin Protein Ligase Activity Spindle Localization Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Germ Cell Development Regulation Of Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Transferase Activity Promoter-specific Chromatin Binding Regulation Of Cell Cycle