MAD2L1

Gene Name		MAD2 mitotic arrest deficient-like 1 (yeast)
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Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Nucleus Nuclear Pore Cytosol Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of APC-Cdc20 Complex Activity Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Amplification of signal from the kinetochores Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		F-cell distribution ( 21326311) HIV-1 viral setpoint ( 22174851)
Protein-protein Interactions		20 interactors: ADAM17 ANAPC2 APP CDC16 CDC20 CDC27 CSF2RB ESR2 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TSC22D4 UBD
Entrez ID		4085
HPRD ID		03274
Ensembl ID
Uniprot IDs		Q13257
PDB IDs		1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Nuclear Division Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cell Division Mitotic Cell Cycle Checkpoint Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Regulation Of Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Mitotic Cell Cycle Regulation Of Cellular Component Organization Mitotic Nuclear Division Negative Regulation Of Proteolysis Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Processing Regulation Of Chromosome Organization Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Protein Processing Negative Regulation Of Protein Ubiquitination Regulation Of Proteolysis Cell Division Negative Regulation Of Cell Cycle Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?		aimed amplification aurka aurkb auroras banding bm carried cdc20 cellularity checkpoint chromosomal cytogenetics developing differ emphasizes fish hematologic hypercellular hypocellular instability logistic malignancies mds mitotic normo qrt solid spindle