MAD2L1 and CDC27

Number of citations: 34 (PubMedID 9736712)
Data Source: HPRD (in vivo)

		MAD2L1	CDC27
Name		mitotic arrest deficient 2 like 1	cell division cycle 27
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Cytoskeleton Mitotic Checkpoint Complex Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Mitotic Spindle
	Molecular Function	Protein Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Protein Phosphatase Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Regulation Of Nuclear Division Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity	Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Neuron Projection Development Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Coronary artery disease ( 28714974 32469254 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) F-cell distribution in sickle cell anaemia ( 21326311 ) HIV-1 viral setpoint ( 22174851 ) Loneliness (multivariate analysis) ( 27629369 ) Myocardial infarction ( 33532862 ) Refractive error ( 32231278 )	Body mass index ( 26426971 ) Diffusing capacity of carbon monoxide ( 30694715 ) Hip circumference adjusted for BMI ( 34021172 )
Novel Interactors		1 novel interactors: BBS7	1 novel interactors: ORMDL3
Interacting Genes		25 interacting genes: ADAM17 ANAPC2 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB DEPDC5 EPM2AIP1 ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD	30 interacting genes: ADNP ANAPC1 ANAPC10 ANAPC2 ANAPC7 BUB1B CASP3 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PABPC4 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBC UBE2S
Entrez ID		4085	996
HPRD ID		03274	00304
Ensembl ID		ENSG00000164109	ENSG00000004897
Uniprot IDs		Q13257	B4DL80 G5EA36 P30260
PDB IDs		1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X 6TLJ	3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9FGQ 9GAW
GO Terms Enriched among Interactors		Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Separation Regulation Of Nuclear Division Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex Regulation Of Cell Cycle Process Regulation Of Meiotic Cell Cycle Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Mitotic Nuclear Division Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Cycle Process Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Separation Metaphase/anaphase Transition Of Cell Cycle Cell Division Regulation Of Reproductive Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Component Organization Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Phase Transition Spindle Negative Regulation Of Cell Cycle Process Protein Branched Polyubiquitination Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint PTB Domain Binding Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Cell Cycle Meiotic Cell Cycle Phase Transition Zeta DNA Polymerase Complex Negative Regulation Of Mitotic Cell Cycle Protein K48-linked Ubiquitination Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Growth	Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Regulation Of Meiotic Cell Cycle Regulation Of Cell Cycle Protein Branched Polyubiquitination Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Segregation Regulation Of Nuclear Division Modification-dependent Protein Catabolic Process Nucleoplasm Regulation Of Chromosome Organization Protein Catabolic Process Proteasomal Protein Catabolic Process Metaphase/anaphase Transition Of Cell Cycle Proteolysis Involved In Protein Catabolic Process Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Binding Protein Polyubiquitination Regulation Of Mitotic Nuclear Division Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Regulation Of Chromosome Separation Ubiquitin Ligase Activator Activity Protein Ubiquitination Post-translational Protein Modification Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification By Small Protein Conjugation Mitotic Checkpoint Complex Positive Regulation Of Mitotic Metaphase/anaphase Transition Protein Modification Process Catabolic Process Protein K48-linked Ubiquitination Proteolysis Positive Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Cytosol Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Positive Regulation Of Chromosome Separation Cell Cycle Phase Transition