DTL and POLH

Number of citations of the paper that reports this interaction (PubMedID 29208956)
70

Data Source:
BioGRID (affinity chromatography technology, pull down)

		DTL	POLH
Description		denticleless E3 ubiquitin protein ligase adapter	DNA polymerase eta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Replication Fork Cytosol Site Of Double-strand Break
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity	DNA Binding Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination Translesion Synthesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle	DNA Synthesis Involved In DNA Repair DNA Replication DNA Repair Regulation Of DNA Repair Pyrimidine Dimer Repair Postreplication Repair DNA Damage Response Response To Radiation Response To UV-C Error-prone Translesion Synthesis Error-free Translesion Synthesis Cellular Response To UV-C DNA Biosynthetic Process
Pathways		Recognition of DNA damage by PCNA-containing replication complex Neddylation	Translesion Synthesis by POLH Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR)
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Height ( 20881960) Large artery stroke ( 28265093) Nickel levels ( 26025379) Plateletcrit ( 32888494)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 POLH TDG TOB1 TP53 UBE2D1 UBE2N	11 interacting genes: APP DDB1 DTL DYNLL1 PCNA POLD2 POLI REV1 RPS27A UBC WBP2
Entrez ID		51514	5429
HPRD ID		17952	04913
Ensembl ID		ENSG00000143476	ENSG00000170734
Uniprot IDs		B4E0E6 F5GZ90 Q9NZJ0	B3KN75 Q9Y253
PDB IDs		6QC0	2I5O 2LSK 3JAA 3MR2 3MR3 3MR5 3MR6 3SI8 3TQ1 3WUP 4DL2 4DL3 4DL4 4DL5 4DL6 4DL7 4ECQ 4ECR 4ECS 4ECT 4ECU 4ECV 4ECW 4ECX 4ECY 4ECZ 4ED0 4ED1 4ED2 4ED3 4ED6 4ED7 4ED8 4EEY 4J9K 4J9L 4J9M 4J9N 4J9O 4J9P 4J9Q 4J9R 4J9S 4O3N 4O3O 4O3P 4O3Q 4O3R 4O3S 4Q8E 4Q8F 4RNM 4RNN 4RNO 4RU9 4YP3 4YQW 4YR0 4YR2 4YR3 5DG7 5DG8 5DG9 5DGA 5DGB 5DLF 5DLG 5DQG 5DQH 5DQI 5EWE 5EWF 5EWG 5F9L 5F9N 5JUM 5KFA 5KFB 5KFC 5KFD 5KFE 5KFF 5KFG 5KFH 5KFI 5KFJ 5KFK 5KFL 5KFM 5KFN 5KFO 5KFP 5KFQ 5KFR 5KFS 5KFT 5KFU 5KFV 5KFW 5KFX 5KFY 5KFZ 5KG0 5KG1 5KG2 5KG3 5KG4 5KG5 5KG6 5KG7 5L1I 5L1J 5L1K 5L1L 5L9X 6D0M 6D0Z 6M7O 6M7P 6M7T 6M7U 6M7V 6MP3 6MQ8 6MXO 6PL7 6PL8 6PLC 6PZ3 6Q02 6UI2 6UQI 6V5K 6W5X 6WK6 7L69 7LCD 7M7L 7M7M 7M7N 7M7O 7M7P 7M7Q 7M7R 7M7S 7M7T 7M7U 7M7Y 7M7Z 7M80 7M81 7M82 7M83 7M84 7M85 7M86 7M87 7M88 7M89 7M8A 7M8B 7M8C 7M8D 7U72 7U73 7U74 7U75 7U76 7U77 7U78 7U79 7U7A 7U7B 7U7C 7U7D 7U7E 7U7F 7U7G 7U7I 7U7J 7U7K 7U7L 7U7R 7U7S 7U7T 7U7U 7U7V 7U7W 7U7X 7U7Y 7U7Z 7U80 7U81 7U82 7U83 7U84 8E85 8E86 8E87 8E88 8E89 8E8A 8E8B 8E8C 8E8D 8E8E 8E8F 8E8G 8E8H 8E8J 8E8K 8EVE 8EVF 8FN3 8FOG 8G8H 8G8J 8GBF 8GKR 8GML 8SKI 8UJT 8UJV 8UJX 8UK4 8V7A 8V7B 8V7C 8V7D 8V7E 8V7F 8V7G 8V7H 8V7I 8V7J 8V7K 9CHW 9CI9 9CIH 9CIQ 9CJ9
Enriched GO Terms of Interacting Partners?		Regulation Of DNA Metabolic Process DNA Metabolic Process DNA Repair DNA Damage Response DNA Replication Regulation Of DNA Replication Cellular Response To Stress Negative Regulation Of Cell Cycle Process Cellular Response To UV DNA Damage Checkpoint Signaling Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cellular Response To Light Stimulus Nucleoplasm Chromatin Organization Replicative Senescence Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Repair Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Response To UV Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region Replication Fork Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle	Translesion Synthesis Postreplication Repair DNA Synthesis Involved In DNA Repair DNA Biosynthetic Process DNA Replication Error-prone Translesion Synthesis Damaged DNA Binding DNA Metabolic Process DNA Damage Response DNA Repair Response To Light Stimulus Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Response To Radiation Nucleoplasm Cellular Response To Stress Cul4A-RING E3 Ubiquitin Ligase Complex DNA Strand Elongation Involved In DNA Replication Protein Tag Activity DNA Strand Elongation DNA-directed DNA Polymerase Activity Macromolecule Metabolic Process Nucleus Nucleic Acid Metabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Nuclear Estrogen Receptor Binding Positive Regulation Of Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Nucleobase-containing Compound Metabolic Process Rhythmic Process Protein Ubiquitination PCNA Complex Replisome Deoxycytidyl Transferase Activity Regulation Of Nitric Oxide Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Endocytic Vesicle Membrane Acetylcholine Receptor Activator Activity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?