DTL and CDT1

Number of citations of the paper that reports this interaction (PMID 24906324)
0

Data Source:
BioGRID (enzymatic study)

		DTL	CDT1
Gene Name		denticleless E3 ubiquitin protein ligase homolog (Drosophila)	chromatin licensing and DNA replication factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	DNA Binding Protein Binding
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Translesion Synthesis G2 DNA Damage Checkpoint Regulation Of Cell Cycle	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Regulation Of DNA-dependent DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication
Pathways			E2F mediated regulation of DNA replication Synthesis of DNA Activation of the pre-replicative complex DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition Activation of the pre-replicative complex S Phase Orc1 removal from chromatin Cell Cycle, Mitotic Assembly of the pre-replicative complex Orc1 removal from chromatin G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins CDT1 association with the CDC6:ORC:origin complex Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Height ( 20881960)	mean corpuscular hemoglobin concentration ( 20139978)
Protein-Protein Interactions		11 interactors: ATR CDT1 CHEK1 CUL4B DDB1 KAT2A PCNA SETD8 TDG TOB1 UBE2D1	29 interactors: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 DDB1 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK1 MCM4 MCM6 MCM7 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		51514	81620
HPRD ID		17952	06900
Ensembl ID		ENSG00000143476	ENSG00000167513
Uniprot IDs		F5GZ90 Q9NZJ0	Q9H211
PDB IDs			2LE8 2WVR
Enriched GO Terms of Interacting Partners?		Cellular Response To UV Cellular Response To Light Stimulus Chromosome Organization DNA Metabolic Process DNA Repair Chromatin Modification Response To UV Chromatin Organization Cellular Response To Radiation Histone Modification Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Cell Cycle Process UV-damage Excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA Replication Mitotic Cell Cycle Process Organelle Organization Negative Regulation Of Biosynthetic Process Response To Light Stimulus Mitotic Cell Cycle Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of DNA Replication Regulation Of Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Replicative Senescence Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Histone Monoubiquitination Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Abiotic Stimulus Regulation Of Metabolic Process Histone Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Process Cellular Response To Stress Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process DNA Replication Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Mitotic Cell Cycle Cellular Protein Catabolic Process Chromosome Organization Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Repair Nucleobase-containing Compound Metabolic Process Mitotic Nuclear Division Regulation Of Protein Ubiquitination G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Organelle Organization Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Negative Regulation Of Mitotic Cell Cycle Cellular Aromatic Compound Metabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process
Tagcloud ?		59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid	assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Difference) ?		59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid	assembled assembling cdc6 creates double generates head helicase heptamer hexamer hexamers hydrolysis interlocked intermediates juxtaposition license licensing loaded loaders mcm2 minichromosome misaligned multisubunit orc origins prereplication recruit replication replicative
Tagcloud (Intersection) ?