DTL and SETD8

Number of citations of the paper that reports this interaction (PMID 20932471)
57

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		DTL	SETD8
Gene Name		denticleless E3 ubiquitin protein ligase homolog (Drosophila)	SET domain containing (lysine methyltransferase) 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	P53 Binding Transcription Corepressor Activity Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Response To UV Translesion Synthesis G2 DNA Damage Checkpoint Regulation Of Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Mitotic Nuclear Division Peptidyl-lysine Monomethylation Histone Lysine Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division
Pathways			Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		11 interactors: ATR CDT1 CHEK1 CUL4B DDB1 KAT2A PCNA SETD8 TDG TOB1 UBE2D1	9 interactors: DTL E2F2 FAM9A HIST4H4 LEF1 PCNA TP53 TWIST1 UBE2I
Entrez ID		51514	387893
HPRD ID		17952	06254
Ensembl ID		ENSG00000143476	ENSG00000183955
Uniprot IDs		F5GZ90 Q9NZJ0	E3VVS3 Q9NQR1
PDB IDs			1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8
Enriched GO Terms of Interacting Partners?		Cellular Response To UV Cellular Response To Light Stimulus Chromosome Organization DNA Metabolic Process DNA Repair Chromatin Modification Response To UV Chromatin Organization Cellular Response To Radiation Histone Modification Cell Cycle Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Process Cellular Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Cell Cycle Process UV-damage Excision Repair Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA Replication Mitotic Cell Cycle Process Organelle Organization Negative Regulation Of Biosynthetic Process Response To Light Stimulus Mitotic Cell Cycle Histone H2A Monoubiquitination Histone H2A Ubiquitination Regulation Of DNA Replication Regulation Of Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Replicative Senescence Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Histone Monoubiquitination Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Abiotic Stimulus Regulation Of Metabolic Process Histone Ubiquitination Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process	Cell Cycle Mitotic Cell Cycle Translesion Synthesis DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Postreplication Repair Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction By P53 Class Mediator Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Gene Expression Negative Regulation Of Striated Muscle Tissue Development Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Neural Crest Cell Migration Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Muscle Organ Development Positive Regulation Of Stem Cell Differentiation Regulation Of Cell Cycle Regulation Of Epithelial To Mesenchymal Transition Base-excision Repair Chromosome Organization T Cell Activation Involved In Immune Response Neural Crest Cell Development Cell Cycle Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Epithelium Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Telomere Maintenance Neural Crest Cell Differentiation Somitogenesis Positive Regulation Of Deoxyribonuclease Activity Cell Proliferation Involved In Heart Valve Development Positive Regulation Of Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Positive Regulation Of SUMO Transferase Activity
Tagcloud ?		59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid	5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379
Tagcloud (Difference) ?		59f5 arm chaperone close closely cluster consisting describe dm dnaj drosophila encodes evolution homolog homology hs hsp90 interspaced isolation kb lethal locus melanogaster nested putative shock spanning temporal tid	5a battery biophysical catalyzes competitive comprehensive discovery extensively h4 h4k20 interesting kmt5a lysine methyltransferase methyltransferases monomethylates monomethylation pcna potencies proliferating pursued quinazoline sar scaffold set7 set8 substituents trends unc0379
Tagcloud (Intersection) ?