TSPAN14 and ATP13A2

Number of citations of the paper that reports this interaction (PubMedID 22645275)
53

Data Source:
BioGRID (two hybrid)

		TSPAN14	ATP13A2
Description		tetraspanin 14	ATPase cation transporting 13A2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Membrane Specific Granule Membrane Tertiary Granule Membrane Tetraspanin-enriched Microdomain	Autophagosome Membrane Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Autophagosome Vesicle Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Late Endosome Membrane Vesicle Multivesicular Body Membrane Neuron Projection Neuronal Cell Body Lysosomal Lumen
	Molecular Function	Protein Binding Enzyme Binding	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Lipid Binding Polyamine Transmembrane Transporter Activity ABC-type Polyamine Transporter Activity P-type Ion Transporter Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Manganese Ion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding P-type Transmembrane Transporter Activity Cupric Ion Binding
	Biological Process	Intracellular Protein Localization Positive Regulation Of Notch Signaling Pathway Protein Maturation Protein Localization To Plasma Membrane	Intracellular Calcium Ion Homeostasis Intracellular Iron Ion Homeostasis Intracellular Zinc Ion Homeostasis Autophagy Lysosomal Transport Positive Regulation Of Gene Expression Regulation Of Mitochondrion Organization Regulation Of Macroautophagy Regulation Of Autophagosome Size Intracellular Monoatomic Cation Homeostasis Regulation Of Intracellular Protein Transport Monoatomic Ion Transmembrane Transport Cellular Response To Oxidative Stress Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Secretion Lipid Homeostasis Protein Localization To Lysosome Autophagosome-lysosome Fusion Cellular Response To Manganese Ion Cellular Response To Zinc Ion Extracellular Exosome Biogenesis Monoatomic Cation Transmembrane Transport Regulation Of Protein Localization To Nucleus Polyamine Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Exosomal Secretion Spermine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Autophagosome Organization Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Lysosomal Protein Catabolic Process
Pathways		Neutrophil degranulation Amyloid fiber formation	Ion transport by P-type ATPases
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Alzheimer's disease ( 33654092) Asthma ( 34103634) Birth weight ( 31043758) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 29212778 33020668) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte count ( 32888494) Monocyte count ( 32888494) Myocardial infarction ( 33532862) Periventricular white matter hyperintensities ( 32517579) Post bronchodilator FEV1 ( 26634245) Pulse pressure ( 30224653) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Severe coronary stenosis (young age of onset interaction) ( 33766035) White blood cell count ( 32888494)	A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 25429064 31562340 20189936) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 28552196 25673412 34021172) Intraocular pressure ( 29617998) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 34021172) Waist-hip index ( 34021172)
Interacting Genes		1 interacting genes: ATP13A2	36 interacting genes: ACKR3 ATP5MC2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 PSME3IP1 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS
Entrez ID		81619	23400
HPRD ID		18196	13677
Ensembl ID		ENSG00000108219	ENSG00000159363
Uniprot IDs		Q8NG11	Q8N4D4 Q8NBS1 Q9NQ11
PDB IDs			7FJM 7FJP 7FJQ 7M5V 7M5X 7M5Y 7N70 7N72 7N73 7N74 7N75 7N76 7N77 7N78 7VPI 7VPJ 7VPK 7VPL 8IEK 8IEL 8IEM 8IEN 8IEO 8IER 8IES
Enriched GO Terms of Interacting Partners?		Polyamine Transmembrane Transporter Activity Extracellular Vesicle Biogenesis Spermine Transport Extracellular Exosome Biogenesis P-type Ion Transporter Activity Negative Regulation Of Lysosomal Protein Catabolic Process P-type Transmembrane Transporter Activity Regulation Of Autophagosome Size Spermine Transmembrane Transport Cupric Ion Binding ABC-type Polyamine Transporter Activity Polyamine Transmembrane Transport Regulation Of Chaperone-mediated Autophagy Cellular Response To Manganese Ion ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Regulation Of Lysosomal Protein Catabolic Process Response To Manganese Ion Autophagosome-lysosome Fusion Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Cellular Response To Zinc Ion Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Multivesicular Body Membrane Intracellular Zinc Ion Homeostasis Vesicle Membrane Response To Zinc Ion Multivesicular Body Regulation Of Autophagy Of Mitochondrion Autophagosome Membrane Protein Localization To Lysosome Manganese Ion Binding Intracellular Iron Ion Homeostasis Autophagosome Positive Regulation Of Exocytosis Lysosomal Lumen Protein Localization To Vacuole Organelle Membrane Fusion Autophagosome Organization Vesicle Fusion Transport Vesicle Regulation Of Mitochondrion Organization Lysosomal Transport Negative Regulation Of Protein Catabolic Process Organelle Fusion Regulation Of Intracellular Protein Transport Late Endosome Membrane Late Endosome Membrane Fusion Regulation Of Protein Localization To Nucleus	Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Endoplasmic Reticulum Membrane G Protein-coupled Receptor Activity Localization Within Membrane C-X-C Chemokine Receptor Activity Endoplasmic Reticulum Coreceptor Activity
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