LBH and CRYAB

Number of citations of the paper that reports this interaction (PubMedID 34000384)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		LBH	CRYAB
Description		LBH regulator of Wnt signaling pathway	crystallin alpha B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Protein-containing Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Surface Z Disc Axon M Band I Band Actin Filament Bundle Protein-containing Complex Dendritic Spine Perikaryon Contractile Muscle Fiber Extracellular Exosome Synaptic Membrane Cardiac Myofibril
	Molecular Function	Protein Binding	Amyloid-beta Binding Structural Molecule Activity Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Cytoskeletal Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Unfolded Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Mammary Gland Development Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mammary Gland Epithelial Cell Differentiation Positive Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Somatic Stem Cell Division Positive Regulation Of Mammary Stem Cell Proliferation Negative Regulation Of Stem Cell Differentiation	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Response To Heat Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Negative Regulation Of Protein-containing Complex Assembly Response To Estradiol Negative Regulation Of Intracellular Transport Protein Refolding Response To Hydrogen Peroxide Camera-type Eye Development Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of DNA-templated Transcription Protein Stabilization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Amyloid Fibril Formation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			HSF1-dependent transactivation
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS		Apolipoprotein A1 levels ( 32203549) Asthma ( 32296059) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) HDL cholesterol levels ( 32203549) Height ( 18391951) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 28714469 27399966 33272962) vWF and FVIII levels ( 21810271) White blood cell count ( 32888494)	Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) PR interval ( 32439900)
Interacting Genes		2 interacting genes: CRYAB PROX1	57 interacting genes: - ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CAPN3 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CRYGS CS DDX20 DES EPB41 FCGR2A FGF2 GFAP GORASP2 HBA1 HSPB1 HSPB2 HSPB6 HSPB8 INS KRTAP19-5 KRTAP6-1 KRTAP8-1 LALBA LBH MDH2 MIP MRPL11 NGF PRKAG3 PRNP PSMA3 RBM11 SCN5A SLC13A1 SNCA SOD1 SQSTM1 TIAM1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		81606	1410
HPRD ID		13965	00428
Ensembl ID		ENSG00000213626	ENSG00000109846
Uniprot IDs		Q53QV2	A0A024R3B9 P02511 V9HW27
PDB IDs			2KLR 2N0K 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3J07 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS 4M5S 4M5T 5VVV 6BP9 7ROJ 9BEE
Enriched GO Terms of Interacting Partners?		Lens Development In Camera-type Eye Otic Placode Formation Hepatocyte Cell Migration Positive Regulation Of Forebrain Neuron Differentiation Branching Involved In Pancreas Morphogenesis Regulation Of Supramolecular Fiber Organization Cardiac Myofibril Cerebellar Granule Cell Differentiation Positive Regulation Of Sarcomere Organization Negative Regulation Of Bile Acid Biosynthetic Process Blood Vessel Endothelial Cell Differentiation Endocardium Formation Olfactory Placode Formation Lymphatic Endothelial Cell Fate Commitment Atrial Cardiac Muscle Tissue Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Forebrain Neuron Differentiation Lens Placode Formation Involved In Camera-type Eye Formation Aorta Smooth Muscle Tissue Morphogenesis Hepatocyte Proliferation Lens Fiber Cell Morphogenesis Lymphatic Endothelial Cell Differentiation DNA Binding Domain Binding LBD Domain Binding Acinar Cell Differentiation Dorsal Spinal Cord Development Ventricular Cardiac Myofibril Assembly Skeletal Muscle Thin Filament Assembly Regulation Of Sarcomere Organization Actin Filament Bundle Venous Blood Vessel Morphogenesis Regulation Of Bile Acid Biosynthetic Process Tubulin Complex Assembly Neuron Fate Determination Regulation Of Growth Regulation Of Bile Acid Metabolic Process Negative Regulation Of Amyloid Fibril Formation Contractile Muscle Fiber Lymph Vessel Development Lymphangiogenesis Hepatocyte Differentiation Retina Morphogenesis In Camera-type Eye Negative Regulation Of Neuroblast Proliferation Lens Morphogenesis In Camera-type Eye Epithelial Cell Fate Commitment Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cardiac Myofibril Assembly Glutamatergic Neuron Differentiation Regulation Of Amyloid Fibril Formation Positive Regulation Of Cell Cycle Checkpoint	Structural Constituent Of Eye Lens Lens Development In Camera-type Eye Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Identical Protein Binding System Process Protein Refolding Regulation Of Transport Response To Metal Ion Regulation Of Autophagy Response To Heat Sensory Perception Regulation Of Multicellular Organismal Process Nervous System Process Apoptotic Process Programmed Cell Death Cellular Response To Metal Ion Positive Regulation Of Growth Cell Death Response To Oxidative Stress Visual Perception Sensory Perception Of Light Stimulus Regulation Of Growth Response To Copper Ion Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Z Disc Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Cellular Response To Stress Response To Unfolded Protein Positive Regulation Of Apoptotic Process Response To Temperature Stimulus Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Programmed Cell Death Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Endocytosis Cytosol Positive Regulation Of Transport Positive Regulation Of Protein Localization Response To Reactive Oxygen Species Positive Regulation Of Cell Growth Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Ovarian Follicle Development
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