GPC1 and SLIT2

Number of citations of the paper that reports this interaction (PMID 11375980)
22

Data Source:
HPRD (in vitro, in vivo)

		GPC1	SLIT2
Gene Name		glypican 1	slit homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Endosome Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Membrane Lysosomal Lumen Membrane Raft Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome
	Molecular Function	Copper Ion Binding Fibroblast Growth Factor Binding Laminin Binding Heparan Sulfate Proteoglycan Binding	GTPase Inhibitor Activity Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding Protein Homodimerization Activity Laminin-1 Binding Proteoglycan Binding Chemorepellent Activity Roundabout Binding
	Biological Process	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Axon Guidance Phototransduction, Visible Light Pathogenesis Schwann Cell Differentiation Heparan Sulfate Proteoglycan Catabolic Process Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Small Molecule Metabolic Process Positive Regulation Of Skeletal Muscle Cell Differentiation	Metanephros Development Ureteric Bud Development In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Leukocyte Chemotaxis Axon Guidance Motor Neuron Axon Guidance Negative Regulation Of Cell Proliferation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Negative Regulation Of Smooth Muscle Cell Migration Single Organismal Cell-cell Adhesion Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Corticospinal Neuron Axon Guidance Through Spinal Cord Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Negative Regulation Of Actin Filament Polymerization Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Dorsal/ventral Axon Guidance Roundabout Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Vascular Permeability Branching Morphogenesis Of An Epithelial Tube Axon Extension Involved In Axon Guidance Positive Regulation Of Axonogenesis Negative Chemotaxis Induction Of Negative Chemotaxis Negative Regulation Of Small GTPase Mediated Signal Transduction Response To Cortisol Mammary Duct Terminal End Bud Growth Apoptotic Process Involved In Luteolysis Negative Regulation Of Chemokine-mediated Signaling Pathway Cellular Response To Heparin Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Axon guidance Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Inactivation of Cdc42 and Rac Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA Activation of Rac MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Role of Abl in Robo-Slit signaling Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS Diseases associated with visual transduction MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates Signaling by Robo receptor HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome	Inactivation of Cdc42 and Rac Role of Abl in Robo-Slit signaling Axon guidance Activation of Rac Regulation of Commissural axon pathfinding by Slit and Robo Netrin-1 signaling Signaling by Robo receptor
Drugs
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125)	Echocardiographic traits ( 17903301)
Protein-Protein Interactions		5 interactors: APP COL18A1 SLIT1 SLIT2 VEGFA	4 interactors: GPC1 ROBO1 ROBO2 UBC
Entrez ID		2817	9353
HPRD ID		02671	04776
Ensembl ID		ENSG00000063660	ENSG00000145147
Uniprot IDs		P35052	O94813
PDB IDs		4ACR 4AD7	2V70 2V9S 2V9T 2WFH
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Involved In Differentiation Regulation Of Developmental Growth Regulation Of Retinal Ganglion Cell Axon Guidance Cell Morphogenesis Regulation Of Axon Extension Dorsal/ventral Axon Guidance Axon Guidance Developmental Cell Growth Growth Axonogenesis Regulation Of Neuron Differentiation Axon Extension Involved In Axon Guidance Regulation Of Cell Size Axon Development Regulation Of Chemotaxis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Developmental Growth Involved In Morphogenesis Regulation Of Growth Cell Growth Neuron Projection Morphogenesis Cell Development Regulation Of Axonogenesis Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Neurogenesis Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Behavior Negative Regulation Of Neuron Differentiation Negative Chemotaxis Neuron Projection Development Cell Migration Involved In Sprouting Angiogenesis Retinal Ganglion Cell Axon Guidance Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Negative Regulation Of Axon Extension Anatomical Structure Morphogenesis Negative Regulation Of Chemotaxis Neuron Development Regulation Of Vascular Permeability Organ Morphogenesis Developmental Growth Negative Regulation Of Neurogenesis Blood Vessel Endothelial Cell Migration Motor Neuron Axon Guidance Neuron Differentiation Regulation Of Cellular Component Size Angiogenesis Negative Regulation Of Cell Development	Negative Regulation Of Negative Chemotaxis Regulation Of Negative Chemotaxis Axon Midline Choice Point Recognition Axon Choice Point Recognition Olfactory Bulb Interneuron Development Olfactory Bulb Interneuron Differentiation Negative Regulation Of Chemotaxis Forebrain Neuron Development Neuron Recognition Axon Guidance Olfactory Bulb Development Olfactory Lobe Development Forebrain Neuron Differentiation Axonogenesis Axon Development Positive Regulation Of Axonogenesis Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Forebrain Generation Of Neurons Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Negative Regulation Of Cellular Response To Growth Factor Stimulus Central Nervous System Neuron Development Neuron Projection Development Cell Recognition Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Regulation Of Chemotaxis Neuron Development Regulation Of Axonogenesis Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Programmed Cell Death Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Heparan Sulfate Proteoglycan Catabolic Process Cell Death Death Cell Morphogenesis Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Behavior Negative Regulation Of Signal Transduction Neuron Differentiation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Projection Organization Pathogenesis Apoptotic Process Involved In Luteolysis Proteoglycan Catabolic Process Roundabout Signaling Pathway Negative Regulation Of Signaling
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing	146a 196a 23b 34a 7c condylomata feature head hpv hpv11 hpv16 hpv6 hr hypermethylation immunohistochemical immunostaining ink4a intronic ki let mir mirnas neck overexpressed p16 panel penile pscc psccs
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 slc12a2 strengths tnik trait unanticipated visualizing	146a 196a 23b 34a 7c condylomata feature head hpv hpv11 hpv16 hpv6 hr hypermethylation immunohistochemical immunostaining ink4a intronic ki let mir mirnas neck overexpressed p16 panel penile pscc psccs
Tagcloud (Intersection) ?