GPC1 and SLIT1

Number of citations of the paper that reports this interaction (PubMedID 10364234)
0

Data Source:
HPRD (in vivo)

		GPC1	SLIT1
Description		glypican 1	slit guidance ligand 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Endosome Golgi Lumen Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Lysosomal Lumen Membrane Raft Synapse Extracellular Exosome Side Of Membrane	Extracellular Region Extracellular Space
	Molecular Function	Copper Ion Binding Protein Binding Fibroblast Growth Factor Binding Laminin Binding	Calcium Ion Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Roundabout Binding
	Biological Process	Regulation Of Signal Transduction Schwann Cell Differentiation Cell Migration Heparan Sulfate Proteoglycan Catabolic Process Myelin Assembly Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Skeletal Muscle Cell Differentiation	Nuclear Migration Nervous System Development Axonogenesis Axon Guidance Motor Neuron Axon Guidance Spinal Cord Development Olfactory Bulb Development Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Tangential Migration From The Subventricular Zone To The Olfactory Bulb Telencephalon Cell Migration Cell Differentiation Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Neuron Projection Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly
Pathways		Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Signaling by ROBO receptors Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions	Netrin-1 signaling Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		BMI x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125)	Bipolar disorder ( 28115744) Diastolic blood pressure (alcohol consumption interaction) ( 24376456) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Obesity-related traits ( 23251661)
Interacting Genes		6 interacting genes: APP COL18A1 SLIT1 SLIT2 UBC VEGFA	17 interacting genes: ADAMTSL4 ATN1 CHRDL2 CYSRT1 FHL5 FXR1 GPC1 HOXA1 KRTAP1-1 KRTAP10-8 KRTAP13-2 KRTAP13-3 MEOX2 MTNR1A ROBO1 TRIM42 ZNF620
Entrez ID		2817	6585
HPRD ID		02671	04773
Ensembl ID		ENSG00000063660	ENSG00000187122
Uniprot IDs		A0A384NPH9 H7C410 P35052	A6H8V1 O75093
PDB IDs		4ACR 4AD7 4BWE 4YWT
Enriched GO Terms of Interacting Partners?		Retinal Ganglion Cell Axon Guidance Heparin Binding Extracellular Space Regulation Of Chemotaxis Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Chemotaxis Roundabout Binding Locomotion System Development Axon Extension Involved In Axon Guidance Developmental Cell Growth Neuron Projection Development Developmental Growth Involved In Morphogenesis Positive Regulation Of Chemotaxis Regulation Of Axonogenesis Regulation Of Axon Extension Involved In Axon Guidance Heparan Sulfate Proteoglycan Binding Negative Regulation Of Vascular Permeability Regulation Of Growth Anatomical Structure Morphogenesis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Olfactory Bulb Development Motor Neuron Axon Guidance Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of MiRNA Transcription Positive Regulation Of Receptor Internalization Neuron Projection Guidance Axon Guidance Regulation Of Leukocyte Migration Regulation Of Monocyte Chemotaxis Chemoattractant Activity Blood Vessel Endothelial Cell Migration Regulation Of Cell Junction Assembly Negative Chemotaxis Plasma Membrane Bounded Cell Projection Organization Telencephalon Cell Migration Positive Chemotaxis Forebrain Cell Migration Axon Extension Regulation Of Vascular Permeability Regulation Of Developmental Growth Negative Regulation Of Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Extracellular Region Regulation Of Neurogenesis Developmental Growth Regulation Of Locomotion Platelet Alpha Granule Lumen Cell Projection Organization	Intermediate Filament Keratin Filament
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