PDK2 and PDHX

Number of citations of the paper that reports this interaction (PMID 12816949)
6

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PDK2	PDHX
Gene Name		pyruvate dehydrogenase kinase, isozyme 2	pyruvate dehydrogenase complex, component X
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex	Mitochondrial Matrix
	Molecular Function	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding Protein Homodimerization Activity	Transferase Activity, Transferring Acyl Groups
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Cellular Metabolic Process Small Molecule Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Pyruvate Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4	8 interactors: ACTN1 AGTRAP DLAT DLD EP300 EWSR1 PDHB PDK2
Entrez ID		5164	8050
HPRD ID		03955	02002
Ensembl ID		ENSG00000005882	ENSG00000110435
Uniprot IDs		B4DLP2 Q15119	E9PB14 O00330
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8	1ZY8 2DNC 2F5Z 2F60
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Hexose Metabolic Process Monocarboxylic Acid Metabolic Process Monosaccharide Metabolic Process Regulation Of Phosphorus Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Plasma Membrane Organic Acid Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Ion Transport Small Molecule Metabolic Process Regulation Of Establishment Of Protein Localization To Plasma Membrane Tricarboxylic Acid Cycle Positive Regulation Of Transport Citrate Metabolic Process Response To Hypoxia Regulation Of T Cell Activation Regulation Of Protein Localization To Plasma Membrane Energy Derivation By Oxidation Of Organic Compounds Regulation Of Metabolic Process Endocrine Pancreas Development Tricarboxylic Acid Metabolic Process Positive Regulation Of Transporter Activity Aerobic Respiration Regulation Of Cell-cell Adhesion Neural Plate Formation Glycogen Cell Differentiation Involved In Embryonic Placenta Development T Cell Costimulation Apoptotic Process Regulation Of Lymphocyte Activation Programmed Cell Death Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Cell Death Death Positive Regulation Of Calcium Ion Transport Pancreas Development Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Cell Activation	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Respiration Monocarboxylic Acid Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Metabolic Process Generation Of Precursor Metabolites And Energy Organic Acid Metabolic Process Histone H2B Acetylation Signal Transduction By P53 Class Mediator Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Phosphorus Metabolic Process N-terminal Peptidyl-lysine Acetylation Protein Localization To Tight Junction Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Regulation Of Tubulin Deacetylation Intrinsic Apoptotic Signaling Pathway Regulation Of Metabolic Process Acetyl-CoA Biosynthetic Process Angiotensin-activated Signaling Pathway Lysine Catabolic Process Protein Localization To Cell Junction Positive Regulation By Host Of Viral Transcription Detoxification Of Mercury Ion Carbohydrate Metabolic Process N-terminal Protein Amino Acid Acetylation Response To Hypoxia Regulation Of Cellular Process Small Molecule Metabolic Process Apoptotic Signaling Pathway Sperm Capacitation Actin Crosslink Formation Branched-chain Amino Acid Catabolic Process Regulation Of Androgen Receptor Signaling Pathway Acetyl-CoA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Mercury Ion N-terminal Protein Amino Acid Modification
Tagcloud ?		addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft	antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Difference) ?		addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft	antigens arrays auc autoantibodies autoantibody diagnostics discriminate discriminatory earliest engineered eventually facile harbored ideally igg igm lgals8 libraries otud6b probed questioned receiver rodent sera stk39 syngeneic tgmmtv vps35 zpf238
Tagcloud (Intersection) ?