PDK2 and VSIG4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PDK2	VSIG4
Description		pyruvate dehydrogenase kinase 2	V-set and immunoglobulin domain containing 4
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Pyruvate Dehydrogenase Complex	Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity	Complement Component C3b Binding Protein Binding
	Biological Process	Glucose Metabolic Process Regulation Of Gluconeogenesis Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Stress Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Immune System Process Complement Activation, Alternative Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Negative Regulation Of Macrophage Activation Innate Immune Response Negative Regulation Of Complement Activation, Alternative Pathway
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases
GWAS			Male-pattern baldness ( 28196072) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4	7 interacting genes: APP C3 FATE1 JAGN1 PDK2 TRIM72 VAMP5
Entrez ID		5164	11326
HPRD ID		03955	02286
Ensembl ID		ENSG00000005882	ENSG00000155659
Uniprot IDs		Q15119	Q9Y279
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2 7EA0 7EAS 7EBH 7VBU 7VBV 7VBX 8ZM1 8ZM2	2ICC 2ICE 2ICF 5IMK 5IML 8TE5 8TE6
Enriched GO Terms of Interacting Partners?		Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Acetyl-CoA Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Pyruvate Metabolic Process Mitochondrion Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Carbohydrate Metabolic Process Phosphate-containing Compound Metabolic Process Mitochondrial Matrix Amide Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Tricarboxylic Acid Cycle Positive Regulation Of Cilium Assembly Protein Kinase Activity Positive Regulation Of Transporter Activity Purine-containing Compound Biosynthetic Process T Cell Costimulation Kinase Activity Sulfur Compound Metabolic Process Regulation Of TRNA Methylation Protein Destabilization Nucleoside Phosphate Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly Regulation Of T Cell Activation Response To Insulin-like Growth Factor Stimulus Regulation Of Leukocyte Cell-cell Adhesion Protein Serine Kinase Activity Mammalian Oogenesis Stage Protein Phosphorylation Regulation Of Glucose Metabolic Process Kinase Binding TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Small Molecule Metabolic Process Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Neuron Remodeling Positive Regulation Of Endocytosis Secretion By Cell Secretion Vesicle-mediated Transport Clathrin-coated Pit Signal Sequence Binding Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Extrinsic Component Of Presynaptic Endocytic Zone Membrane Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Phosphorus Metabolic Process Monoatomic Ion Homeostasis Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Stress Amylin Binding Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Receptor-mediated Endocytosis Receptor Ligand Activity Positive Regulation Of Receptor-mediated Endocytosis Monoatomic Cation Homeostasis Defense Response To Fungus Response To Fungus Regulation Of Calcium-mediated Signaling Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Response To Other Organism Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process
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