PDK2 and HIC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		PDK2	HIC2
Description		pyruvate dehydrogenase kinase 2	HIC ZBTB transcriptional repressor 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Pyruvate Dehydrogenase Complex	Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Glucose Metabolic Process Regulation Of Gluconeogenesis Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Stress Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases
GWAS			Mean corpuscular volume ( 20139978) Systemic lupus erythematosus ( 19838193)
Interacting Genes		10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4	9 interacting genes: APP CCNT1 CEP70 CRBN EHMT2 HIC1 MFHAS1 PDK2 ZBTB8A
Entrez ID		5164	23119
HPRD ID		03955	07412
Ensembl ID		ENSG00000005882	ENSG00000169635
Uniprot IDs		Q15119	Q96JB3
PDB IDs		2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2 7EA0 7EAS 7EBH 7VBU 7VBV 7VBX 8ZM1 8ZM2	7TXC
Enriched GO Terms of Interacting Partners?		Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Acetyl-CoA Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Pyruvate Metabolic Process Mitochondrion Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Carbohydrate Metabolic Process Phosphate-containing Compound Metabolic Process Mitochondrial Matrix Amide Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Tricarboxylic Acid Cycle Positive Regulation Of Cilium Assembly Protein Kinase Activity Positive Regulation Of Transporter Activity Purine-containing Compound Biosynthetic Process T Cell Costimulation Kinase Activity Sulfur Compound Metabolic Process Regulation Of TRNA Methylation Protein Destabilization Nucleoside Phosphate Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly Regulation Of T Cell Activation Response To Insulin-like Growth Factor Stimulus Regulation Of Leukocyte Cell-cell Adhesion Protein Serine Kinase Activity Mammalian Oogenesis Stage Protein Phosphorylation Regulation Of Glucose Metabolic Process Kinase Binding TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Small Molecule Metabolic Process Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Acetylcholine Receptor Activator Activity Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex PTB Domain Binding Regulation Of Wnt Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Spontaneous Synaptic Transmission Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of JNK Cascade Negative Regulation Of RNA Biosynthetic Process Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Negative Regulation Of Transcription By RNA Polymerase II NMDA Selective Glutamate Receptor Signaling Pathway Amylin Binding Positive Regulation Of JNK Cascade Regulation Of Synapse Structure Or Activity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Adult Behavior Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Negative Regulation Of DNA-templated Transcription Regulation Of Toll Signaling Pathway Regulation Of Calcium-mediated Signaling Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling P-TEFb Complex Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Phenotypic Switching Histone H3K56 Methyltransferase Activity Peptidyl-lysine Dimethylation Histone H3K27 Methyltransferase Activity
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