PDCD1LG2 and TMEM147

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDCD1LG2	TMEM147
Description		programmed cell death 1 ligand 2	transmembrane protein 147
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Nuclear Membrane Protein-containing Complex Multi-pass Translocon Complex
	Molecular Function	Protein Binding	Protein Binding Ribosome Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide	Protein Localization To Nuclear Inner Membrane Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways		Co-inhibition by PD-1 PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Serum alkaline phosphatase levels ( 33339817)	Alanine aminotransferase levels ( 33547301) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		20 interacting genes: ATP6V0C ERMP1 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35H1 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97	61 interacting genes: ABHD16A ABI3 BIK CD40 CD79A CLDN7 CLN8 CLRN1 CREB3L1 CXCR2 CYB5R3 DPM3 EBP EFNA4 ENPP4 ERGIC3 F11R FAM209A FFAR2 FKBP7 GJA8 GLP1R GOLM1 GPR101 GPR37L1 GPR42 GPR61 HTR2C IL3RA KASH5 LDLRAD1 LEUTX LHFPL2 MTIF3 MUC1 PDCD1LG2 PSCA PVR RMDN3 RNF185 SAR1A SCAMP4 SHISA3 SLC10A1 SLC12A7 SLC13A4 SLC18A1 SLC22A1 SLC22A2 SLC35H1 SUSD3 SYNE4 TACR1 TEX29 TMEM14B TMEM237 TMEM248 TMEM252 TMEM42 TMEM52B TSPAN12
Entrez ID		80380	10430
HPRD ID		16147	17633
Ensembl ID		ENSG00000197646	ENSG00000105677
Uniprot IDs		Q9BQ51	Q9BVK8
PDB IDs		6UMT 8J3V	6W6L 9C7U 9C7V
Enriched GO Terms of Interacting Partners?		Membrane Glutamine Transport L-glutamine Transmembrane Transporter Activity Amino Acid Transmembrane Transport Amino Acid Transport	Membrane Neurotransmitter Reuptake Norepinephrine Uptake Serotonin Uptake Norepinephrine Transport Neurotransmitter Uptake Monoamine Transmembrane Transporter Activity Plasma Membrane G Protein-coupled Receptor Activity Catecholamine Uptake Dopamine Uptake Serotonin Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Protein Binding Xenobiotic Transmembrane Transporter Activity Dopamine Transport Acetylcholine Transport Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Monoamine Transport Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Actin-based Cell Projection Neurotransmitter Transport Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Meiotic Nuclear Membrane Microtubule Tethering Complex Transmembrane Transport Amine Transport Organic Cation Transmembrane Transporter Activity Azole Transmembrane Transport Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
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