PDCD1LG2 and TAS2R10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDCD1LG2	TAS2R10
Description		programmed cell death 1 ligand 2	taste 2 receptor member 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Endomembrane System Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Protein Binding Taste Receptor Activity Bitter Taste Receptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Activated T Cell Proliferation Cellular Response To Lipopolysaccharide	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Taste
Pathways		Co-inhibition by PD-1 PD-L1(CD274) glycosylation and translocation to plasma membrane	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Serum alkaline phosphatase levels ( 33339817)
Interacting Genes		20 interacting genes: ATP6V0C ERMP1 GALNT15 GPR37L1 KTN1 LRP10 MFSD6 PDCD1 RUSF1 SLC35H1 SLC38A1 SLC38A7 SLC41A2 SLC7A1 SMIM3 TAS2R10 TMEM147 TMEM218 TMEM239 TMEM97	4 interacting genes: HERPUD2 PDCD1LG2 RTP4 SSMEM1
Entrez ID		80380	50839
HPRD ID		16147	11990
Ensembl ID		ENSG00000197646	ENSG00000121318
Uniprot IDs		Q9BQ51	Q9NYW0
PDB IDs		6UMT 8J3V
Enriched GO Terms of Interacting Partners?		Membrane Glutamine Transport L-glutamine Transmembrane Transporter Activity Amino Acid Transmembrane Transport Amino Acid Transport
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