REEP4 and SQLE

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		REEP4	SQLE
Description		receptor accessory protein 4	squalene epoxidase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Cytoplasmic Microtubule Membrane Endoplasmic Reticulum Tubular Network	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Microtubule Binding	Squalene Monooxygenase Activity Protein Binding Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Lipid Droplet Formation Response To Biphenyl
Pathways			Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs			Naftifine Terbinafine Butenafine Ellagic acid
Diseases
GWAS		Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)	Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Metabolite levels ( 23823483)
Interacting Genes		101 interacting genes: AGPAT4 ARLN BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 NINJ2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM14B TMEM167B TMEM18 TMEM19 TMEM208 TMEM229B TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VMA12 VTI1B YIF1A YIPF4 YIPF6	8 interacting genes: ALDOC BCL2L13 CREB3 CREB3L1 MARCHF6 REEP4 TMEM14B ZNF641
Entrez ID		80346	6713
HPRD ID		09864	11802
Ensembl ID		ENSG00000168476	ENSG00000104549
Uniprot IDs		E5RGS2 Q9H6H4	Q14534
PDB IDs			6C6N 6C6P 6C6R
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endomembrane System SNAP Receptor Activity SNARE Complex Protein Binding Establishment Of Protein Localization Organelle Fusion Vesicle Fusion Organelle Membrane Fusion Mitochondrial Outer Membrane Membrane Fusion Membrane Organization Vesicle Fusion With Golgi Apparatus Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Docking Protein Transport Presynaptic Endosome Membrane Golgi Vesicle Transport Monoatomic Ion Transmembrane Transporter Activity Intracellular Transport Cellular Localization Mitochondrial Membrane Nitric-oxide Synthase Complex Vesicle Organization Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Serine Import Into Mitochondrion Olfactory Receptor Binding Establishment Of Localization In Cell Myelination Axon Ensheathment Nitrite Reductase (NO-forming) Activity Transport Vesicle Golgi Membrane Vesicle Docking Menaquinone Metabolic Process SNARE Binding Golgi Organization Import Into The Mitochondrion Bcl-2 Family Protein Complex Mitochondrial Transport	ADP Catabolic Process Pyruvate Metabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Response To Endoplasmic Reticulum Stress ER Ubiquitin Ligase Complex Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Response To Unfolded Protein Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Fructose-bisphosphate Aldolase Activity Extracellular Matrix Constituent Secretion Glucose Metabolic Process Nucleoside Phosphate Catabolic Process Release From Viral Latency ATP Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Organophosphate Catabolic Process Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Metabolic Process Carbohydrate Derivative Metabolic Process CAMP Response Element Binding Protein Binding Mitotic Nuclear Membrane Reassembly Negative Regulation Of Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process CAMP Response Element Binding Fructose Metabolic Process Endoplasmic Reticulum Mannose Trimming
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