EDEM3 and TRA

Number of citations of the paper that reports this interaction (PubMedID 29784879)
43

Data Source:
BioGRID (pull down)

		EDEM3	TRA
Description		ER degradation enhancing alpha-mannosidase like protein 3	T cell receptor alpha locus
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Metal Ion Binding	Signaling Receptor Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Endoplasmic Reticulum Mannose Trimming	Adaptive Immune Response Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Bacterium
Pathways		ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189) Waist circumference adjusted for body mass index ( 34021172)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Narcolepsy ( 24204295) Periodontal disease-related phenotype (Socransky) ( 26962152)
Interacting Genes		2 interacting genes: TRA TXNDC5	16 interacting genes: CANX CD247 CD3D CD3G EDEM3 HLA-A HLA-B HLA-DRB1 HSPA5 LEF1 NCOA6 SNTA1 TMUB1 TRAT1 TRB TRD
Entrez ID		80267	6955
HPRD ID		10724	01736
Ensembl ID		ENSG00000116406
Uniprot IDs		A0A8J8YX80 Q9BZQ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell T Cell Mediated Cytotoxicity T Cell Receptor Complex Beta-catenin Destruction Complex Nuclear Envelope Lumen S100 Protein Binding Response To Growth Hormone Intracellular Organelle Lumen Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Protein-lysine N-methyltransferase Activity	Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Lumenal Side Of Endoplasmic Reticulum Membrane Detection Of Biotic Stimulus Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Detection Of Bacterium T Cell Receptor Binding Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Immune System Process ERAD Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Gamma-delta T Cell Receptor Complex Antigen Processing And Presentation Of Endogenous Antigen TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding T Cell Activation Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune Response External Side Of Plasma Membrane Immune System Process Protection From Natural Killer Cell Mediated Cytotoxicity Immune Response-activating Signaling Pathway Immune Response To Tumor Cell ER To Golgi Transport Vesicle Membrane Immune Response-regulating Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen MHC Class I Protein Complex Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Immune Response Clathrin-coated Endocytic Vesicle Membrane Regulation Of Immune System Process Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Lymphocyte Activation Protein Folding In Endoplasmic Reticulum Positive Thymic T Cell Selection Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Detection Of Stimulus Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Positive T Cell Selection Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation
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