EDEM3 and TXNDC5

Number of citations of the paper that reports this interaction (PubMedID 29784879)
43

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		EDEM3	TXNDC5
Description		ER degradation enhancing alpha-mannosidase like protein 3	thioredoxin domain containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Azurophil Granule Lumen Lysosomal Lumen Intracellular Organelle Lumen Extracellular Exosome
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Metal Ion Binding	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Isomerase Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Endoplasmic Reticulum Mannose Trimming	Protein Folding Negative Regulation Of Apoptotic Process
Pathways		ER Quality Control Compartment (ERQC)	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)
Interacting Genes		2 interacting genes: TRA TXNDC5	29 interacting genes: APP AR BLZF1 CEBPA EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2
Entrez ID		80267	81567
HPRD ID		10724	18249
Ensembl ID		ENSG00000116406	ENSG00000239264
Uniprot IDs		A0A8J8YX80 Q9BZQ6	A0A024QZV0 Q8NBS9
PDB IDs			2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX 8EKY
Enriched GO Terms of Interacting Partners?		Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell T Cell Mediated Cytotoxicity T Cell Receptor Complex Beta-catenin Destruction Complex Nuclear Envelope Lumen S100 Protein Binding Response To Growth Hormone Intracellular Organelle Lumen Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Protein-lysine N-methyltransferase Activity	Keratin Filament Intermediate Filament Protein Glycosylation Macromolecule Glycosylation Glycosylation Hair Cycle
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