DBF4B and ROPN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DBF4B	ROPN1
Description		DBF4B-CDC7 kinase regulatory subunit	rhophilin associated tail protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Dbf4-dependent Protein Kinase Complex	Nucleus Cytoplasm Cilium Motile Cilium Cell Projection
	Molecular Function	Nucleic Acid Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition	Flagellated Sperm Motility Cilium Organization Sperm Capacitation Protein Localization To Cilium
Pathways			RHO GTPases Activate Rhotekin and Rhophilins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Household income ( 31844048) Household income (MTAG) ( 31844048)
Interacting Genes		17 interacting genes: CDC7 CYSRT1 GEM HEXIM2 HOXA1 KDM1A KRTAP4-12 LMO2 LRRK2 MDFI PCSK5 ROPN1 SGF29 SRPK2 SUV39H1 TRIM27 ZNF655	50 interacting genes: AKAIN1 AKAP14 AKAP3 AKAP5 AKAP7 AP1M1 BTBD16 CDC37 CEP57L1 CKS1B CNST DBF4B ERCC3 FAM110A FAM153A FAM153B FAM161A FAM90A1 GNL3L GPKOW HNRNPUL1 KIAA0753 KIF9 LENG1 LMO4 LNX1 LNX2 NTAQ1 PICK1 PKP2 POLR3C PRDM6 PRKAA1 PSMA1 RHPN1 RTP5 SDCBP SERTAD1 SORBS3 SPA17 SPG21 SYTL4 TRIM3 TSGA10IP TSHZ3 TSNAXIP1 TULP3 UBE2W VPS33A XKR3
Entrez ID		80174	54763
HPRD ID		16840	15269
Ensembl ID		ENSG00000161692	ENSG00000065371
Uniprot IDs		Q8NFT6	A0A140VKB2 Q9HAT0
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Mitotic Spindle Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Epigenetic Regulation Of Gene Expression Regulation Of Cell Cycle Magnesium Ion Binding Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Semicircular Canal Formation Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Determination Of Adult Lifespan Regulation Of DNA Repair Regulation Of Neuroblast Proliferation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly	Protein Kinase A Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
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