NAA15 and XRCC5

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology)
HPRD (in vitro)

		NAA15	XRCC5
Description		N-alpha-acetyltransferase 15, NatA auxiliary subunit	X-ray repair cross complementing 5
Image
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm Cytosol Membrane Nuclear Body NatA Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Extracellular Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Small-subunit Processome Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex DNA-dependent Protein Kinase Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Acetyltransferase Activator Activity Acetyltransferase Activity Ribosome Binding	Nucleotide Binding Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding Enzyme Activator Activity ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding U3 SnoRNA Binding Telomeric DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Angiogenesis N-terminal Protein Amino Acid Acetylation Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Protein Stabilization	Telomere Maintenance Recombinational Repair Activation Of Innate Immune Response Immune System Process DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Telomere Maintenance Via Telomerase Negative Regulation Of Macromolecule Biosynthetic Process Neurogenesis Regulation Of Telomere Maintenance Small-subunit Processome Assembly Ribosome Biogenesis Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Hematopoietic Stem Cell Proliferation Cellular Response To Gamma Radiation Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor
Pathways			2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
Drugs
Diseases
GWAS
Interacting Genes		10 interacting genes: CDC42 CEBPA HYPK NAA10 NAA11 NAA50 RNF10 RPL26 XRCC5 XRCC6	59 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 DEAF1 DUX4 ELF3 ERCC6 GZMA GZMB HSF1 HSPB1 LIG3 LINC01554 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC PTEN RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A
Entrez ID		80155	7520
HPRD ID		10471	08935
Ensembl ID		ENSG00000164134	ENSG00000079246
Uniprot IDs		A0A0B4J1W3 B2RBE5 Q9BXJ9	P13010
PDB IDs		6C95 6C9M 6PPL 6PW9 9F1B 9F1C 9F1D 9FPZ 9FQ0	1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH 6ZH6 6ZHA 6ZHE 7AXZ 7K0Y 7K17 7K1J 7K1K 7K1N 7LSY 7LT3 7NFC 7NFE 7SGL 7SU3 7SUD 7Z6O 7Z87 7Z88 7ZT6 7ZVT 7ZWA 7ZYG 8AG4 8AG5 8ASC 8BH3 8BHV 8BHY 8BOT 8EZA 8EZB 8RD4
Enriched GO Terms of Interacting Partners?		Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex N-terminal Protein Amino Acid Acetylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Cellular Response To Gamma Radiation DNA End Binding Ku70:Ku80 Complex Protein N-terminal-serine Acetyltransferase Activity Protein Acetylation Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups DNA-dependent Protein Kinase Complex Response To Gamma Radiation Nucleolus DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Ionizing Radiation Nonhomologous End Joining Complex Transcription Cis-regulatory Region Binding Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Chromosome Organization Protein-containing Complex Response To Ionizing Radiation Acyltransferase Activity Hematopoietic Stem Cell Proliferation Telomeric DNA Binding Cellular Response To Radiation ATP-dependent Activity, Acting On DNA DNA Helicase Activity Protein-DNA Complex Macrophage Differentiation Double-strand Break Repair Via Nonhomologous End Joining RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Translation Involved In Cellular Response To UV Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Damaged DNA Binding Protein Maturation Positive Regulation Of Protein Metabolic Process Stem Cell Proliferation Regulation Of Cell Development Protein-containing Complex Binding Macromolecule Metabolic Process GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Organelle Organization Regulation Of Cell Population Proliferation	DNA Metabolic Process Nucleic Acid Metabolic Process Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Positive Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Telomere Maintenance Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process DNA Binding Response To Gamma Radiation Regulation Of RNA Metabolic Process Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Macromolecule Biosynthetic Process Telomere Organization Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Replication Regulation Of Double-strand Break Repair Chromatin Binding Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromosome Organization Positive Regulation Of DNA-templated Transcription DNA Recombination Negative Regulation Of DNA Metabolic Process DNA Strand Elongation Regulation Of Gene Expression Recombinational Repair Response To Ionizing Radiation
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