MYO15B and KLF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYO15B	KLF4
Description		myosin XVB	KLF transcription factor 4
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GO Annotations	Cellular Component		Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function		Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Chromatin DNA Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Defense Response To Tumor Cell DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Population Proliferation Epidermis Development Epidermal Cell Differentiation Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Negative Regulation Of Cell Migration Epithelial Cell Differentiation Post-embryonic Camera-type Eye Development Positive Regulation Of Telomere Maintenance Response To Retinoic Acid Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Population Maintenance Post-embryonic Hemopoiesis Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Establishment Of Skin Barrier Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Blastocyst Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes Positive Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS			Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Coronary artery disease ( 33020668) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 34059833 28898252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Heel bone mineral density ( 28869591 30598549) Myocardial infarction ( 33532862) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)
Interacting Genes		96 interacting genes: ABI2 ADAMTSL4 BEND7 C7orf57 CARD9 CCNC CEP57L1 CFAP68 COIL CRX DNAJA3 DUSP21 ERAS FAM9B FHL2 GAB2 GADD45GIP1 GFAP GINS3 GPRASP3 HOXA1 IHO1 IKZF3 KATNBL1 KCNJ6 KIAA0408 KIF24 KIFC3 KLF4 KLHL12 KRT13 KRT31 KRT34 KRT35 KRT75 LIMS1 MTUS2 MYOZ3 NADSYN1 NBPF19 NDUFA12 NECAB2 NEDD4 NEFL NHSL2 NKAPD1 NOTCH2NLA NR1D2 NUP62 PAK5 PKNOX2 PLEKHA3 PNMA1 PNMA5 POU6F2 PPM1K PRKAR1B RAD54B RBM11 RCN1 RCN3 REL RPH3AL RUNDC3A SAXO4 SLA SORBS3 SPATC1L SPRED2 SSBP4 TCF12 TCF4 TEX13A TFIP11 TLE5 TPRN TRAF2 TRIM14 TRIM27 TRIM29 TRIM54 TSC22D4 UBQLN2 VGLL3 ZBED1 ZBTB10 ZBTB3 ZBTB32 ZBTB8A ZCCHC14 ZMAT1 ZNF114 ZNF438 ZNF774 ZNF837 ZNRD2	24 interacting genes: APP CREBBP DVL3 ELK1 FBXO7 GYS1 HDAC1 HDAC5 HGS HSF2BP KAT5 KLF6 LINC00629 MYO15B PAX9 PLK1 SETD7 SP1 TLE5 TP53 USP10 USP17L2 VHL ZNF750
Entrez ID		80022	9314
HPRD ID			03769
Ensembl ID		ENSG00000266714	ENSG00000136826
Uniprot IDs		Q96JP2 Q9H614	O43474
PDB IDs		2DLP	6VTX
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Intermediate Filament Organization Protein Binding Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis Intermediate Filament Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of RNA Metabolic Process Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Chromatin Remodeling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Binding Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Double-strand Break Repair Regulation Of Programmed Cell Death Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding Histone Deacetylase Binding Regulation Of Developmental Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm DNA Damage Response, Signal Transduction By P53 Class Mediator Autophagy Negative Regulation Of Macromolecule Metabolic Process Signal Transduction In Response To DNA Damage DNA Repair
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