MYO15B and PPM1K

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYO15B	PPM1K
Description		myosin XVB	protein phosphatase, Mg2+/Mn2+ dependent 1K
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GO Annotations	Cellular Component		Mitochondrion Mitochondrial Matrix
	Molecular Function		Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Manganese Ion Binding Cation Binding Metal Ion Binding [3-methyl-2-oxobutanoate Dehydrogenase (lipoamide)]-phosphatase Activity
	Biological Process		Branched-chain Amino Acid Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Intracellular Signal Transduction
Pathways			Branched-chain amino acid catabolism H139Hfs13* PPM1K causes a mild variant of MSUD
Drugs
Diseases
GWAS			Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Coffee consumption (cups per day) ( 25288136) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Metabolite levels ( 22286219 22916037) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 32514006)
Interacting Genes		96 interacting genes: ABI2 ADAMTSL4 BEND7 C7orf57 CARD9 CCNC CEP57L1 CFAP68 COIL CRX DNAJA3 DUSP21 ERAS FAM9B FHL2 GAB2 GADD45GIP1 GFAP GINS3 GPRASP3 HOXA1 IHO1 IKZF3 KATNBL1 KCNJ6 KIAA0408 KIF24 KIFC3 KLF4 KLHL12 KRT13 KRT31 KRT34 KRT35 KRT75 LIMS1 MTUS2 MYOZ3 NADSYN1 NBPF19 NDUFA12 NECAB2 NEDD4 NEFL NHSL2 NKAPD1 NOTCH2NLA NR1D2 NUP62 PAK5 PKNOX2 PLEKHA3 PNMA1 PNMA5 POU6F2 PPM1K PRKAR1B RAD54B RBM11 RCN1 RCN3 REL RPH3AL RUNDC3A SAXO4 SLA SORBS3 SPATC1L SPRED2 SSBP4 TCF12 TCF4 TEX13A TFIP11 TLE5 TPRN TRAF2 TRIM14 TRIM27 TRIM29 TRIM54 TSC22D4 UBQLN2 VGLL3 ZBED1 ZBTB10 ZBTB3 ZBTB32 ZBTB8A ZCCHC14 ZMAT1 ZNF114 ZNF438 ZNF774 ZNF837 ZNRD2	14 interacting genes: AATK BIRC2 ERBB3 HSF2BP HSPB2 LMTK2 MAGEA11 MYB MYO15B NTAQ1 PTK7 UBXN11 XIAP ZNF410
Entrez ID		80022	152926
HPRD ID			15167
Ensembl ID		ENSG00000266714	ENSG00000163644
Uniprot IDs		Q96JP2 Q9H614	Q8N3J5
PDB IDs		2DLP	2IQ1 4DA1 6AK7
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Intermediate Filament Organization Protein Binding Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Supramolecular Fiber Organization Structural Constituent Of Skin Epidermis Intermediate Filament Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of RNA Metabolic Process Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Keratin Filament DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding	Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Polyubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Neuron Apoptotic Process Regulation Of Protein Polyubiquitination
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