FRMD1 and PIN4

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		FRMD1	PIN4
Description		FERM domain containing 1	peptidylprolyl cis/trans isomerase, NIMA-interacting 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasmic Side Of Apical Plasma Membrane	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Spindle Cytoskeleton Preribosome
	Molecular Function	Protein Binding	DNA Binding Bent DNA Binding Double-stranded DNA Binding RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity
	Biological Process	Positive Regulation Of Hippo Signaling	RRNA Processing
Pathways
Drugs
Diseases
GWAS		Immune reponse to smallpox (secreted IL-2) ( 22610502) Metabolite levels ( 23823483) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Autism spectrum disorder ( 34069769) Rosacea symptom severity ( 29771307)
Interacting Genes		2 interacting genes: PIN4 RAB2A	19 interacting genes: ASCC2 CEBPA CEP72 CSNK2A1 CSNK2A2 DNM1 EGFR ERBB2 ERBB3 ERBB4 EZH2 FAM9B FATE1 FBL FRMD1 MAGEA11 PNMA1 SPTAN1 ZBTB9
Entrez ID		79981	5303
HPRD ID		10997	02219
Ensembl ID		ENSG00000153303	ENSG00000102309
Uniprot IDs		A0A2R8Y4L9 A0A2R8Y6M2 A0A2R8Y7X7 Q8N878	Q9Y237
PDB IDs			1EQ3 1FJD 3UI4 3UI5 3UI6
Enriched GO Terms of Interacting Partners?		Preribosome Bent DNA Binding Autophagosome-lysosome Fusion	ERBB2 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB3:ERBB2 Complex ERBB Signaling Pathway Protein Kinase CK2 Complex Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Identical Protein Binding Gland Development Protein Tyrosine Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regeneration Protein Kinase Activity Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Animal Organ Regeneration Negative Regulation Of Apoptotic Process ERBB2-EGFR Signaling Pathway Negative Regulation Of Programmed Cell Death ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Kinase Activity Protein-containing Complex Localization Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chromosome Separation Animal Organ Development Regulation Of Apoptotic Process Positive Regulation Of Protein Phosphorylation Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Protein Tyrosine Kinase Activator Activity Basolateral Plasma Membrane Positive Regulation Of Growth Positive Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Metabolic Process Liver Development Positive Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Catabolic Process Embryonic Placenta Development
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