TOB2

Description		transducer of ERBB2, 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Transcription Corepressor Activity Protein Binding Nuclear Vitamin D Receptor Binding
	Biological Process	Female Gamete Generation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278) Vitiligo ( 22561518)
Interacting Genes		7 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 PABPC1 RPS6KA1 TMEM132D
Entrez ID		10766
HPRD ID		09583
Ensembl ID		ENSG00000183864
Uniprot IDs		Q14106
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Translation Positive Regulation Of MRNA Catabolic Process CCR4-NOT Complex CCR4-NOT Core Complex Poly(A)-specific Ribonuclease Activity Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA Metabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulatory NcRNA-mediated Gene Silencing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Post-transcriptional Regulation Of Gene Expression RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability 3'-5'-RNA Exonuclease Activity Positive Regulation Of Viral Genome Replication MiRNA-mediated Gene Silencing By MRNA Destabilization Exonuclease Activity Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of Viral Process Regulation Of Viral Genome Replication Cytoplasmic Ribonucleoprotein Granule MRNA Destabilization P-body RNA Destabilization MiRNA-mediated Post-transcriptional Gene Silencing Regulation Of Viral Life Cycle Nuclease Activity Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Catabolic Process Nucleic Acid Binding Post-transcriptional Gene Silencing Regulation Of Viral Process MRNA Metabolic Process PiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Protein Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation MRF Binding MCRD-mediated MRNA Stability Complex Ribosomal Protein S6 Kinase Activity Hepatocyte Proliferation PiRNA Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay CRD-mediated MRNA Stabilization
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