ATAD5 and RAD9A

Number of citations of the paper that reports this interaction (PubMedID 15983387)
27

Data Source:
HPRD (in vitro)

		ATAD5	RAD9A
Description		ATPase family AAA domain containing 5	RAD9 checkpoint clamp component A
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GO Annotations	Cellular Component	Nucleus Elg1 RFC-like Complex	Nucleus Nucleoplasm Cytoplasm Checkpoint Clamp Complex
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity DNA Clamp Unloader Activity	Nuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Hydrolase Activity SH3 Domain Binding Enzyme Binding Protein Kinase Binding Histone Deacetylase Binding
	Biological Process	DNA Damage Response Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of B Cell Proliferation Nuclear DNA Replication Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Isotype Switching Positive Regulation Of DNA Replication Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Cycle G2/M Phase Transition	DNA Replication Checkpoint Signaling DNA Damage Checkpoint Signaling DNA Repair DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Ionizing Radiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body mass index ( 28892062) Breast cancer ( 25751625 29059683) Diastolic blood pressure ( 30224653) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 23563607 18391951) Hip circumference adjusted for BMI ( 25673412 34021172) Lung cancer in ever smokers ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500 34021172)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		2 interacting genes: PCNA RAD9A	39 interacting genes: ABL1 AR ATAD5 ATM BCL2 BCL2L1 CAD CDK1 CHEK2 CLSPN COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEM1B FEN1 HDAC1 HUS1 HUS1B ITSN2 MLH1 MSH2 MSH3 MSH6 NR3C1 OGG1 PCNA POLB PRKCE RAD17 RAD9B RHNO1 RPA1 RPA2 SF3B3 TDG TLK1 TOPBP1 WRN
Entrez ID		79915	5883
HPRD ID		07792	04788
Ensembl ID		ENSG00000176208	ENSG00000172613
Uniprot IDs		Q96QE3	Q99638
PDB IDs		8UI7 8UI8 8UI9 8UII	3A1J 3G65 3GGR 6HM5 6J8Y 7Z6H 8GNN 8JZY 8WU8
Enriched GO Terms of Interacting Partners?		PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Cellular Response To Radiation Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation Enzyme Binding Checkpoint Clamp Complex Response To Radiation Double-stranded DNA 3'-5' DNA Exonuclease Activity DNA Repair MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Regulation Of Cellular Response To Stress Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Estrous Cycle Nuclear Lamina DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling DNA Strand Elongation Nuclear Replication Fork Response To L-glutamate DNA Metabolic Process DNA Damage Response Ovulation Cycle DNA Replication Checkpoint Signaling 3'-5' Exonuclease Activity Mitotic Intra-S DNA Damage Checkpoint Signaling DNA Polymerase Binding Translesion Synthesis Histone Acetyltransferase Binding Replication Fork Liver Regeneration Mismatch Repair Postreplication Repair Replication Fork Processing Nuclear Estrogen Receptor Binding DNA Synthesis Involved In DNA Repair Response To Cadmium Ion Positive Regulation Of DNA Replication Response To Dexamethasone Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of DNA Biosynthetic Process Exonuclease Activity Male Germ Cell Nucleus	DNA Damage Response DNA Repair DNA Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling DNA Recombination Double-strand Break Repair Mitotic DNA Damage Checkpoint Signaling Nucleic Acid Metabolic Process Mitotic DNA Integrity Checkpoint Signaling Mismatch Repair Response To Stress Regulation Of Cell Cycle Process Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Macromolecule Metabolic Process Nucleoplasm Intracellular Signal Transduction Response To Ionizing Radiation Response To Radiation Damaged DNA Binding Nucleus Regulation Of DNA Metabolic Process Protein Localization To Site Of Double-strand Break Recombinational Repair Mitotic Intra-S DNA Damage Checkpoint Signaling Base-excision Repair Enzyme Binding Regulation Of Mitotic Cell Cycle DNA Replication Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Response To Stress Chromosome, Telomeric Region Somatic Cell DNA Recombination Mitotic DNA Replication Checkpoint Signaling Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Negative Regulation Of DNA Recombination Mismatched DNA Binding Regulation Of DNA Recombination Guanine/thymine Mispair Binding Mitotic G2/M Transition Checkpoint
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