TUT4

Description		terminal uridylyl transferase 4
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GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity MiRNA Binding Metal Ion Binding RNA Uridylyltransferase Activity
	Biological Process	Oocyte Maturation MiRNA Metabolic Process MiRNA Catabolic Process Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Histone MRNA Catabolic Process Transposable Element Silencing By MRNA Destabilization Polyuridylation-dependent MRNA Catabolic Process
Pathways		Deadenylation of mRNA Zygotic genome activation (ZGA) Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: CYP27B1
Interacting Genes		13 interacting genes: CPSF7 FXR2 MIR143 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I YBX2
Entrez ID		23318
HPRD ID		15700
Ensembl ID		ENSG00000134744
Uniprot IDs		Q5TAX3
PDB IDs		6IW6 8OST
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-10 Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translation Regulation Of Endothelial Cell Migration Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Cellular Response To Amyloid-beta Regulation Of Multicellular Organismal Process Positive Regulation Of Catabolic Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Response To Amyloid-beta
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