TUT4 and MIRLET7D

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		TUT4	MIRLET7D
Description		terminal uridylyl transferase 4	microRNA let-7d
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Cytosol Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity MiRNA Binding Metal Ion Binding RNA Uridylyltransferase Activity
	Biological Process	Oocyte Maturation MiRNA Metabolic Process MiRNA Catabolic Process Stem Cell Population Maintenance Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing Histone MRNA Catabolic Process Transposable Element Silencing By MRNA Destabilization Polyuridylation-dependent MRNA Catabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		Deadenylation of mRNA Zygotic genome activation (ZGA) Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: CPSF7 FXR2 MIR143 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7C MIRLET7D MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I YBX2	100 interacting genes: AIMP1 APOBEC3B AQR ATXN2L C1QBP CDC5L CHERP CPSF6 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PUF60 PUM1 PURA QARS1 RARS1 RBM10 RBM12B RBM14 RBM4 RBM4B RBM5 RBM6 RTCB SAFB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SLTM SPOUT1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		23318	406886
HPRD ID		15700
Ensembl ID		ENSG00000134744	ENSG00000199133
Uniprot IDs		Q5TAX3
PDB IDs		6IW6 8OST
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Gene Expression Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MRNA Destabilization RNA Destabilization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Positive Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Interleukin-8 Production Negative Regulation Of Interleukin-10 Production Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translation Regulation Of Endothelial Cell Migration Calcidiol 1-monooxygenase Activity Secalciferol 1-monooxygenase Activity Cellular Response To Amyloid-beta Regulation Of Multicellular Organismal Process Positive Regulation Of Catabolic Process Regulation Of Cell Migration Involved In Sprouting Angiogenesis Response To Amyloid-beta	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing Macromolecule Metabolic Process Nucleus Post-transcriptional Regulation Of Gene Expression Nucleoplasm MiRNA Binding Spliceosomal Complex Regulation Of MRNA Processing Ribonucleoprotein Complex Aminoacyl-tRNA Synthetase Multienzyme Complex Catalytic Step 2 Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Translation Cytoplasmic Stress Granule Regulation Of Gene Expression Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Negative Regulation Of Translation TRNA Aminoacylation Nucleolus Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cytoplasmic Translation Positive Regulation Of Gene Expression
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