Wiki-Pi
About
Search
People
Updates
Search
IRF6 and RFX3
Number of citations of the paper that reports this interaction (PubMedID
20211142
)
41
Data Source:
BioGRID
(two hybrid)
IRF6
RFX3
Description
interferon regulatory factor 6
regulatory factor X3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Chromatin
Extracellular Region
Nucleus
Transcription Regulator Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Keratinocyte Proliferation
Cell Differentiation
Keratinocyte Differentiation
Skin Development
Keratinocyte Proliferation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Cell Development
Roof Of Mouth Development
Limb Development
Mammary Gland Epithelial Cell Differentiation
Stem Cell Proliferation
Cranial Skeletal System Development
Negative Regulation Of Stem Cell Proliferation
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Determination Of Left/right Symmetry
Cell Differentiation
Endocrine Pancreas Development
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Regulation Of Insulin Secretion
Cilium Assembly
Cilium-dependent Cell Motility
Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry
Type B Pancreatic Cell Maturation
Positive Regulation Of Type B Pancreatic Cell Development
Pathways
Interferon gamma signaling
Interferon alpha/beta signaling
Drugs
Diseases
IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS)
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS
Alopecia areata (
25608926
)
Alzheimer's disease (APOE e4 interaction) (
25778476
)
Cleft lip (
20436469
)
Crohn's disease (
28067908
)
Drug-induced liver injury in interferon-beta-treated multiple sclerosis (
30013178
)
Inflammatory bowel disease (
28067908
)
Nonsyndromic cleft lip (
31609978
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Nonsyndromic cleft lip with or without cleft palate (
25775280
33898419
)
Nonsyndromic cleft palate (
31609978
)
Orofacial clefts (
19270707
22863734
)
Systolic blood pressure (
30224653
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Body mass index (
28552196
)
Gout (
25967671
)
Insomnia (
29520036
)
Major depressive disorder (
27479909
)
Monobrow thickness (
26926045
)
Smoking status (ever vs never smokers) (
30643258
)
Systolic blood pressure in sickle cell anemia (
24058526
)
Weight (
28552196
)
Interacting Genes
4 interacting genes:
IRF8
RFX3
TLX2
ZBTB3
13 interacting genes:
BIN1
CREB1
EWSR1
FHL2
FHL3
IRF6
MEOX2
PKNOX1
RFX1
RFX4
RFX6
TRAF2
TRIP6
Entrez ID
3664
5991
HPRD ID
06227
03215
Ensembl ID
ENSG00000117595
ENSG00000080298
Uniprot IDs
G0Z349
O14896
P48380
PDB IDs
Enriched GO Terms of Interacting Partners
?
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
Sequence-specific Double-stranded DNA Binding
Plasmacytoid Dendritic Cell Differentiation
Positive Regulation Of Type B Pancreatic Cell Development
Type B Pancreatic Cell Maturation
DNA Binding
Plasmacytoid Dendritic Cell Activation
Follicular B Cell Differentiation
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Ciliary Transition Fiber
Pronucleus
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Transcription Cis-regulatory Region Binding
Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Dendrite Morphogenesis
Germinal Center B Cell Differentiation
Kinetochore Assembly
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Enteric Nervous System Development
Positive Regulation Of Transcription By RNA Polymerase II
Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry
Negative Regulation Of RNA Metabolic Process
Kinetochore Organization
Regulation Of Metabolic Process
Endocrine Pancreas Development
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Activity
Regulation Of RNA Metabolic Process
Chromatin
Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Sequence-specific Double-stranded DNA Binding
Ventricular Cardiac Muscle Cell Development
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Regulation Of Gene Expression
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Z Disc
Lipid Tube
Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pronuclear Fusion
Epithelial Cell Differentiation
Cardiac Muscle Cell Development
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Cardiac Cell Development
DNA Binding
Response To Cocaine
Chemotaxis To Arachidonate
TORC2 Complex Disassembly
N-acetylneuraminate Synthase Activity
N-acylneuraminate-9-phosphate Synthase Activity
Pancreatic Epsilon Cell Differentiation
Regulation Of Macromolecule Metabolic Process
Hsp70 Protein Binding
Nucleus
Lipid Tube Assembly
Negative Regulation Of Cardiac Muscle Cell Contraction
Mitotic DNA-templated DNA Replication
Cyclin B1-CDK1 Complex
Cyclin A1-CDK1 Complex
Cyclin A2-CDK1 Complex
Positive Regulation Of Cardiac Muscle Tissue Development
Sequence-specific DNA Binding
Positive Regulation Of Transforming Growth Factor Beta3 Production
Positive Regulation Of Transcription By RNA Polymerase II
Atrial Cardiac Muscle Cell Development
Limb Development
TRAF2-GSTP1 Complex
TORC1 Complex Assembly
CD40 Receptor Binding
Nucleoside Triphosphate Adenylate Kinase Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?