IRF6 and RFX3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		IRF6	RFX3
Gene Name		interferon regulatory factor 6	regulatory factor X, 3 (influences HLA class II expression)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	Regulatory Region DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Cell Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation	Type B Pancreatic Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Endocrine Pancreas Development Cilium Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Regulation Of Insulin Secretion Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Cleft lip ( 20436469) Orofacial clefts ( 19270707 22863734)
Protein-Protein Interactions		5 interactors: IRF8 LBP RFX3 TLX2 ZBTB3	12 interactors: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6
Entrez ID		3664	5991
HPRD ID		06227	03215
Ensembl ID		ENSG00000117595	ENSG00000080298
Uniprot IDs		G0Z349 O14896	P48380
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Growth Of Symbiont In Host Cellular Response To Lipopolysaccharide Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Type B Pancreatic Cell Maturation Lipopolysaccharide Transport Transcription, DNA-templated Cellular Response To Molecule Of Bacterial Origin RNA Biosynthetic Process Defense Response To Bacterium Cilium-dependent Cell Motility Positive Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Growth Phagocytosis Glandular Epithelial Cell Maturation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway RNA Metabolic Process Positive Regulation Of Respiratory Burst Response To Lipopolysaccharide Negative Regulation Of Dendrite Morphogenesis Response To Molecule Of Bacterial Origin Gene Expression Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Positive Regulation Of Cytokine Production Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Opsonization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Positive Regulation Of Macrophage Activation Macromolecule Biosynthetic Process Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of DNA-templated Transcription, Initiation Enteric Nervous System Development Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Cellular Response To Lipid Regulation Of Metabolic Process Negative Regulation Of Dendrite Development Type B Pancreatic Cell Development Leukocyte Migration Involved In Inflammatory Response Regulation Of DNA-templated Transcription, Initiation Response To Bacterium Defense Response To Protozoan Regulation Of Tumor Necrosis Factor Biosynthetic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Organ Development System Development I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pancreatic D Cell Differentiation Pancreatic Epsilon Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Toll-like Receptor 4 Signaling Pathway Lipid Tube Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Localization Toll-like Receptor Signaling Pathway Atrial Cardiac Muscle Cell Development Developmental Process Muscle Structure Development Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Cellular Response To Inorganic Substance Epithelial Cell Differentiation Activation Of Innate Immune Response
Tagcloud ?		cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine	1b bipolar brains butyrate deacetylases division exert f1bgfp facilitates fgf fgf1 fibroblast gfp glycogen gsk hdac lithium mood neurogenesis neuroprotective nspcs recapitulate rfx2 sirnas stabilizing trichostatin valproic vpa
Tagcloud (Difference) ?		cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine	1b bipolar brains butyrate deacetylases division exert f1bgfp facilitates fgf fgf1 fibroblast gfp glycogen gsk hdac lithium mood neurogenesis neuroprotective nspcs recapitulate rfx2 sirnas stabilizing trichostatin valproic vpa
Tagcloud (Intersection) ?