IRF6

Description		interferon regulatory factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Differentiation Keratinocyte Differentiation Skin Development Keratinocyte Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Limb Development Mammary Gland Epithelial Cell Differentiation Stem Cell Proliferation Cranial Skeletal System Development Negative Regulation Of Stem Cell Proliferation
Pathways		Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases		IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS) Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
GWAS		Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734) Systolic blood pressure ( 30224653)
Novel Interacting Genes		1 novel interacting genes: CENPF
Interacting Genes		4 interacting genes: IRF8 RFX3 TLX2 ZBTB3
Entrez ID		3664
HPRD ID		06227
Ensembl ID		ENSG00000117595
Uniprot IDs		G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Plasmacytoid Dendritic Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Development Type B Pancreatic Cell Maturation DNA Binding Plasmacytoid Dendritic Cell Activation Follicular B Cell Differentiation Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Ciliary Transition Fiber Pronucleus Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Dendrite Morphogenesis Germinal Center B Cell Differentiation Kinetochore Assembly Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enteric Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Negative Regulation Of RNA Metabolic Process Kinetochore Organization Regulation Of Metabolic Process Endocrine Pancreas Development
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