ST7 and CUL4A

Number of citations of the paper that reports this interaction (PubMedID 30945288)
0

Data Source:
BioGRID (enzymatic study)

		ST7	CUL4A
Description		suppression of tumorigenicity 7	cullin 4A
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Extracellular Matrix Organization Regulation Of Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair
Pathways			Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 30591961) Response to alcohol consumption (flushing response) ( 29460428) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Apolipoprotein A1 levels ( 32203549) Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756 34002096) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Intracranial aneurysm ( 30823506) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 27863252 32888494) Red cell distribution width ( 32888494)
Interacting Genes		9 interacting genes: ACTN2 CUL4A CUL4B DCAF4 MYOT NFKBIA RACK1 SNAPIN ZFYVE9	25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M
Entrez ID		7982	8451
HPRD ID		09015	07218
Ensembl ID		ENSG00000004866	ENSG00000139842
Uniprot IDs		B7Z4L1 B7Z4U3 E7EPD9 E7EPW5 G3XAH9 H7BXS2 Q9NRC1 X5DRA0	A0A087WWN2 A0A0A0MR50 Q13619
PDB IDs			2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I
Enriched GO Terms of Interacting Partners?		Cul4-RING E3 Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Regulation Of Cellular Localization Positive Regulation Of Protein Catabolic Process Protein Ubiquitination Structural Constituent Of Muscle Regulation Of Intracellular Transport Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Actin Filament Uncapping Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Late Endosome To Lysosome Transport Post-translational Protein Modification Titin Z Domain Binding Negative Regulation Of Transport Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To UV Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting Phospholipase C-activating Angiotensin-activated Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Light Stimulus Ribosome Biogenesis Positive Regulation Of Mitotic Cell Cycle Microspike Assembly Z Disc Positive Regulation Of Intracellular Transport FATZ Binding Regulation Of Vesicle-mediated Transport Mitotic Cell Cycle Phase Transition Positive Regulation Of Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal Negative Regulation Of Translational Elongation Terminal Button Organization Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Response To UV Cell Cycle Phase Transition Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Golgi To Plasma Membrane Protein Transport BH3 Domain Binding	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence
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