MOB3B and STK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MOB3B	STK3
Description		MOB kinase activator 3B	serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Protein-containing Complex
	Molecular Function	Protein Binding Protein Kinase Activator Activity Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Signal Transduction Regulation Of Hippo Signaling	Neural Tube Formation Endocardium Development Protein Phosphorylation Protein Import Into Nucleus Apoptotic Process Signal Transduction JNK Cascade Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Gene Expression Organ Growth Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Protein Tetramerization Centrosome Separation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Protein Localization To Centrosome Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Signaling by Hippo
Drugs			Fostamatinib
Diseases
GWAS		Adult asthma ( 27611488) Asthma ( 27611488) Delirium ( 29631748) Plasma trimethylamine N-oxide levels ( 28439531) Urinary symptoms in response to radiotherapy in prostate cancer ( 23376709)	Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		6 interacting genes: LATS1 LATS2 MAPK14 NT5C2 PPBP STK3	41 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GABARAP GABARAPL1 GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS2 LRRK2 MAP1LC3B MAP1LC3C MARK2 MBP MOB3B MOB4 MPP1 OGT ORM2 PEX19 PIN1 QARS1 RAF1 RASSF4 SAV1 SLMAP SNIP1 SULT2A1 TFPT TRAF1 TRIM21 TRIM69 ZC3H7A
Entrez ID		79817	6788
HPRD ID		14728	05433
Ensembl ID		ENSG00000120162	ENSG00000104375
Uniprot IDs		Q86TA1	A0A087WZ06 A0A384MR07 Q13188
PDB IDs			3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2 8A66
Enriched GO Terms of Interacting Partners?		Regulation Of Hippo Signaling Regulation Of Organ Growth Positive Regulation Of Hippo Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Hippo Signaling Negative Regulation Of Wnt Signaling Pathway Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Developmental Growth Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Transferase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Nucleus Protein Kinase Activity Spindle Pole Cell Morphogenesis Regulation Of Growth D-glucose Transmembrane Transport Kinase Activity ATP Binding Hexose Transmembrane Transport Canonical Inflammasome Complex Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Protein Metabolic Process Carbohydrate Transmembrane Transport Protein Modification Process Carbohydrate Transport Negative Regulation Of Protein Localization To Nucleus Regulation Of NLRP3 Inflammasome Complex Assembly Nucleotide Binding Protein Phosphorylation Negative Regulation Of Cell Cycle Keratinocyte Differentiation Positive Regulation Of Fat Cell Differentiation Phosphorylation Negative Regulation Of Protein Kinase Activity Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Negative Regulation Of Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Epidermal Cell Differentiation Canonical Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation	Cellular Response To Nitrogen Starvation Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Regulation Of Hippo Signaling Cytoplasm Mitophagy Autophagosome Cellular Response To Nutrient Levels Autophagosome Assembly Vacuole Organization Cellular Response To Starvation Autophagosome Organization Regulation Of Intracellular Signal Transduction Autophagy Autophagosome Maturation Positive Regulation Of Proteolysis Intracellular Signal Transduction Autophagosome Membrane Response To Starvation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosol Protein-containing Complex Disassembly Negative Regulation Of Hippo Signaling Hippo Signaling Apoptotic Process Macroautophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Programmed Cell Death Protein Binding Cell Death Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Organ Growth Signal Transduction Protein-containing Complex Organization Positive Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Pyroptotic Inflammatory Response Regulation Of Protein Metabolic Process Protein Phosphorylation Positive Regulation Of Proteasomal Protein Catabolic Process Protein Serine Kinase Activity
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