FAM184A and AMOTL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FAM184A	AMOTL2
Description		family with sequence similarity 184 member A	angiomotin like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Cytoplasm Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body	Podosome Cytoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Junction Cytoplasmic Vesicle Cell Projection Recycling Endosome Anchoring Junction
	Molecular Function	Protein Binding	Protein Binding Actin Filament Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Endothelial Cell Morphogenesis Establishment Of Cell Polarity Involved In Ameboidal Cell Migration Wnt Signaling Pathway Actin Cytoskeleton Organization Regulation Of Cell Migration Hippo Signaling Positive Regulation Of Protein Localization
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Parkinson's disease progression (composite) ( 33111402) Parkinson's disease progression (motor) ( 33111402) Schizophrenia ( 30285260)	Cadmium levels ( 26025379) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte fraction of red cells ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		11 interacting genes: AMOTL2 APP BRAP BRCA1 GOLGA2 LRRK1 LRRK2 MAP3K1 MTDH PPP1R13B VPS52	92 interacting genes: AMOT BFSP2 BLZF1 BRMS1L BYSL CARD9 CCDC185 CCDC196 CCDC57 CCHCR1 CDC37 CDR2 CHCHD3 CINP CYTH4 DAXX DDIT3 DSCAM DTNB DYNLL1 DZIP1L EIF4E2 FAM184A FAM90A1 FBXO7 FCRL5 FXR2 GCC1 GNG11 GNG5 GOLGA2 GSTM5 KIF9 KRT1 KRT13 KRT15 KRT19 KRT20 KRT31 KRT38 KRTAP10-5 KRTAP4-2 L3MBTL2 LMNB2 LMO3 LMO4 MAD1L1 MAGEA4 MAGOHB MFAP1 MORF4L2 MPP1 MTCL2 MTMR6 MTNR1A MYO5B NDC80 NF2 NFIL3 NME7 NTAQ1 PIBF1 PPP2CA PPP2R1A PRKAA2 PRPF18 PSMC3 RAD51D RALBP1 RASAL3 RASSF5 RNF20 RNF40 RNF8 SAAL1 SH3RF2 SMARCE1 SP100 SPAG5 SPOP SPP1 TCEA2 THRA TMCC2 TNKS2 TRAF2 TRIM27 TSGA10IP YES1 ZBED1 ZBTB16 ZGPAT
Entrez ID		79632	51421
HPRD ID		09856	16485
Ensembl ID		ENSG00000111879	ENSG00000114019
Uniprot IDs		H7BY63 Q6P9G8 Q8NB25	Q9Y2J4
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Cellular Response To Manganese Ion Golgi-associated Vesicle Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process Cellular Response To Catecholamine Stimulus Signal Transduction Response To Catecholamine Response To Manganese Ion MAP Kinase Kinase Kinase Activity Amyloid-beta Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Cytoplasm Modulation Of Excitatory Postsynaptic Potential Identical Protein Binding Centrosome Cycle Syntaxin Binding MAPK Cascade Embryonic Ectodermal Digestive Tract Development Nuclear Membrane Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Tubulin Binding Myeloid Cell Development Acetylcholine Receptor Activator Activity Regulation Of Wnt Signaling Pathway Endosome Cell Surface Receptor Signaling Pathway Lipoprotein Particle Positive Regulation Of Protein Import Histone H2AK127 Ubiquitin Ligase Activity P53 Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding PTB Domain Binding	Keratin Filament Intermediate Filament Intermediate Filament Organization Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Protein Binding Identical Protein Binding Structural Constituent Of Cytoskeleton Cytoskeleton Organization Ubiquitin Protein Ligase Binding Structural Molecule Activity Nucleus Cytosol Centriolar Satellite Organelle Organization Protein Polyubiquitination Centrosome Chromosome, Centromeric Region HULC Complex PML Body Supramolecular Fiber Organization Ubiquitin Ligase Complex Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Primary Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Cell Cycle
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