DHX40 and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DHX40	PSTPIP1
Description		DEAH-box helicase 40	proline-serine-threonine phosphatase interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Spliceosomal Complex	Uropod Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Lamellipodium Cleavage Furrow Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity	Protein Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome	Immune System Process Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Innate Immune Response
Pathways			The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases			Pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome
GWAS			Hip circumference adjusted for BMI ( 34021172) Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: FBXO7 PSTPIP1 USP7	64 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		79665	9051
HPRD ID		06346	05891
Ensembl ID		ENSG00000108406	ENSG00000140368
Uniprot IDs		B4DR88 Q8IX18	A0A0S2Z5P3 J3KPG6 O43586
PDB IDs			2DIL 7AAL 7AAM 7AAN
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Autophagy Symbiont-mediated Disruption Of Host Cell PML Body Lewy Body Core Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Protein Stability Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Autophagy Monoubiquitinated Protein Deubiquitination DNA Alkylation Repair Regulation Of Telomere Capping Transcription-coupled Nucleotide-excision Repair Uropod Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Catabolic Process K48-linked Deubiquitinase Activity Negative Regulation Of Gluconeogenesis Protein Ubiquitination Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Deubiquitinase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion	Actin Filament Polymerization Protein Polymerization MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Actin Polymerization Or Depolymerization SH3 Domain Binding Negative Regulation Of Membrane Tubulation Protein Binding Regulation Of Plasma Membrane Organization MRNA Processing RNA Splicing MRNA Metabolic Process Regulation Of ERBB Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Spliceosomal Tri-snRNP Complex Regulation Of Double-strand Break Repair Regulation Of DNA Repair Negative Regulation Of ERBB Signaling Pathway Lamellipodium Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin Filament Organization Podosome Regulation Of Vitamin D Receptor Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Spliceosomal Complex Actin Cytoskeleton Ruffle SCAR Complex
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