THOC6 and DDX39B

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down)

		THOC6	DDX39B
Description		THO complex subunit 6	DExD-box helicase 39B
Image
GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Transcription Export Complex Nucleus Nucleoplasm Spliceosomal Complex U4 SnRNP U6 SnRNP Cytoplasm Nuclear Speck
	Molecular Function	RNA Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity U6 SnRNA Binding U4 SnRNA Binding Identical Protein Binding ATP-dependent Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus Apoptotic Process Central Nervous System Development RNA Splicing MRNA Transport	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle
Drugs			Artenimol
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) High light scatter reticulocyte count ( 32888494) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean platelet volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Myositis ( 26291516) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: ALYREF DDX39B PTEN	31 interacting genes: ALYREF BARD1 DDX39A DNM2 EXOSC9 FANCA HIPK2 HNRNPLL IL7R LUZP4 NCBP2 OGT PIAS2 PKM RBM39 RNF4 RPS15A SARNP SDCBP SNRPA SREBF1 SREK1 SRPK2 STRN4 TDG THOC3 THOC6 TUBB3 UBE2I YWHAG ZHX1
Entrez ID		79228	7919
HPRD ID		14504	00805
Ensembl ID		ENSG00000131652	ENSG00000198563
Uniprot IDs		Q86W42	A0A024RCM3 Q13838
PDB IDs		7APK 7ZNK 7ZNL	1T5I 1T6N 1XTI 1XTJ 1XTK 7APK 7ZNK 7ZNL 8ENK
Enriched GO Terms of Interacting Partners?		Transcription Export Complex RNA Export From Nucleus MRNA Export From Nucleus Osteoblast Differentiation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spliceosomal Complex RNA Transport MRNA Transport Nuclear Export Nucleobase-containing Compound Transport Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Nuclear Transport Nucleocytoplasmic Transport MRNA Binding C5-methylcytidine-containing RNA Reader Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly ATP-dependent Protein Binding U4 SnRNA Binding Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly U6 SnRNP ATP-dependent Activity, Acting On RNA RNA Splicing Postsynaptic Specialization Assembly Presynaptic Membrane Organization Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential Nuclear Speck MRNA Processing U4 SnRNP Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Maternal Behavior U6 SnRNA Binding	RNA Binding Nucleoplasm MRNA Metabolic Process Nucleus Nuclear Speck Nuclear Export MRNA Export From Nucleus MRNA Transport MRNA Processing Transcription Export Complex RNA Export From Nucleus RNA Transport RNA Splicing Nucleic Acid Metabolic Process Nucleobase-containing Compound Transport Macromolecule Metabolic Process RNA Processing Nucleobase-containing Compound Metabolic Process Nuclear Transport Nucleocytoplasmic Transport RNA Metabolic Process PML Body Nucleic Acid Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein K6-linked Ubiquitination Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II THO Complex Part Of Transcription Export Complex U1 SnRNP Binding MRNA Binding Regulation Of MRNA Processing Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of MRNA 3'-end Processing Regulation Of Macromolecule Metabolic Process Response To Insulin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process
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