THOC6 and ALYREF

Number of citations of the paper that reports this interaction (PMID 17190602)
119

Data Source:
BioGRID (affinity chromatography technology, pull down)

		THOC6	ALYREF
Gene Name		THO complex 6 homolog (Drosophila)	Aly/REF export factor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Nucleus Nucleoplasm Nuclear Speck	Transcription Export Complex Nucleus Nucleoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding	Nucleotide Binding Single-stranded DNA Binding Protein Binding Poly(A) RNA Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus Apoptotic Process Central Nervous System Development RNA Splicing Negative Regulation Of Apoptotic Process Viral MRNA Export From Host Cell Nucleus	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus
Pathways			Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript Transport of Mature mRNAs Derived from Intronless Transcripts Transport of the SLBP independent Mature mRNA Cleavage of Growing Transcript in the Termination Region mRNA Splicing - Major Pathway mRNA 3'-end processing Transport of Mature Transcript to Cytoplasm RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: ALYREF DDX39B	11 interactors: AKT1 DDX39B IL7R LEF1 MAGOH NXF1 RUNX2 THOC1 THOC6 THOC7 UPF3A
Entrez ID		79228	10189
HPRD ID		14504	09168
Ensembl ID		ENSG00000131652	ENSG00000183684
Uniprot IDs		Q86W42	E9PB61 Q86V81
PDB IDs			3ULH
Enriched GO Terms of Interacting Partners?		Viral MRNA Export From Host Cell Nucleus Intracellular Transport Of Virus Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of DNA-templated Transcription, Elongation MRNA Export From Nucleus RNA Export From Nucleus Nuclear Export MRNA Transport RNA Transport RNA Localization Viral Life Cycle MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleocytoplasmic Transport Nuclear Transport RNA Splicing RNA Secondary Structure Unwinding Negative Regulation Of DNA Damage Checkpoint MRNA Processing MRNA Metabolic Process Viral Process RNA Processing Cytoplasmic Transport Regulation Of DNA Damage Checkpoint Replication Fork Processing Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Transport Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Spliceosomal Complex Assembly Regulation Of DNA Recombination DNA-templated Transcription, Termination MRNA 3'-end Processing Establishment Of Localization In Cell RNA 3'-end Processing DNA-dependent DNA Replication Cellular Localization Regulation Of Response To DNA Damage Stimulus Osteoblast Differentiation Positive Regulation Of Cellular Metabolic Process Ribonucleoprotein Complex Assembly RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression DNA Replication Ossification Ribonucleoprotein Complex Biogenesis	MRNA Transport Nucleocytoplasmic Transport Nuclear Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Viral MRNA Export From Host Cell Nucleus Nuclear Export Cytoplasmic Transport Intracellular Transport Of Virus Intracellular Transport Gene Expression MRNA Metabolic Process RNA Splicing Establishment Of Localization In Cell Regulation Of Cell Cycle Checkpoint MRNA Processing Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Gene Expression Viral Life Cycle Cellular Localization Viral Process RNA Processing Regulation Of DNA Damage Checkpoint RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Osteoblast Differentiation T Cell Differentiation Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Adaptive Immune Response B Cell Proliferation Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Activation Regulation Of Translation Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Aggregation T Cell Activation Ossification Lymphocyte Aggregation Leukocyte Aggregation
Tagcloud ?			ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet
Tagcloud (Difference) ?			ablated amyotrophic atg biosamples c9orf72 crosslinking dipeptide exclusive expansions export foci ggggcc ggggcc5 hnrnp inappropriate irreversible lateral licensing messenger missing proteome pulldown repeat rnase sclerosis sequester sequestration srsf2 ultraviolet
Tagcloud (Intersection) ?