THOC6 and ALYREF

Number of citations of the paper that reports this interaction (PubMedID 15998806)
35

Data Source:
BioGRID (affinity chromatography technology, pull down)

		THOC6	ALYREF
Description		THO complex subunit 6	Aly/REF export factor
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body Nuclear Speck	Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding C5-methylcytidine-containing RNA Reader Activity
	Biological Process	MRNA Processing MRNA Export From Nucleus Apoptotic Process Central Nervous System Development RNA Splicing MRNA Transport	Osteoblast Differentiation MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS
Interacting Genes		3 interacting genes: ALYREF DDX39B PTEN	13 interacting genes: AKT1 CEBPA DDX39B ESR1 FOXP1 IL7R LEF1 MAGOH NXF1 PTEN RUNX2 THOC6 UPF3A
Entrez ID		79228	10189
HPRD ID		14504	09168
Ensembl ID		ENSG00000131652	ENSG00000183684
Uniprot IDs		Q86W42	E9PB61 Q86V81
PDB IDs		7APK 7ZNK 7ZNL	3ULH 7ZNJ 7ZNK
Enriched GO Terms of Interacting Partners?		Transcription Export Complex RNA Export From Nucleus MRNA Export From Nucleus Osteoblast Differentiation Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Spliceosomal Complex RNA Transport MRNA Transport Nuclear Export Nucleobase-containing Compound Transport Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Nuclear Transport Nucleocytoplasmic Transport MRNA Binding C5-methylcytidine-containing RNA Reader Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Peptidyl-serine Phosphorylation Postsynaptic Density Assembly ATP-dependent Protein Binding U4 SnRNA Binding Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly U6 SnRNP ATP-dependent Activity, Acting On RNA RNA Splicing Postsynaptic Specialization Assembly Presynaptic Membrane Organization Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential Nuclear Speck MRNA Processing U4 SnRNP Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Maternal Behavior U6 SnRNA Binding	Nucleoplasm MRNA Transport RNA Transport Transcription Export Complex MRNA Export From Nucleus RNA Export From Nucleus Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport Cell Development Positive Regulation Of Cell Population Proliferation RNA Metabolic Process Nuclear Export Osteoblast Differentiation Mononuclear Cell Differentiation T Cell Differentiation Leukocyte Differentiation Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Gene Expression Nitric-oxide Synthase Regulator Activity Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Animal Organ Development Nucleic Acid Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Transcription Regulator Complex Lymphocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Regulation Of Organ Growth Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Tumor Necrosis Factor Myelin Maintenance Nucleus T Cell Activation Beta-catenin Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Biosynthetic Process Osteoblast Development Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-binding Transcription Factor Activity
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