GPANK1 and NR1H3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPANK1	NR1H3
Description		G-patch domain and ankyrin repeats 1	nuclear receptor subfamily 1 group H member 3
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleic Acid Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Cholesterol Binding Chromatin DNA Binding Sterol Response Element Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Lipid Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Lipid Storage Negative Regulation Of Cholesterol Storage Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Lipid Transport Positive Regulation Of Cholesterol Transport Response To Progesterone Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Circadian Rhythm MRNA Transcription By RNA Polymerase II Negative Regulation Of Macrophage Activation Apoptotic Cell Clearance Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Pinocytosis Negative Regulation Of Inflammatory Response Lipid Homeostasis Sterol Homeostasis Negative Regulation Of Type II Interferon-mediated Signaling Pathway Triglyceride Homeostasis Cellular Response To Lipopolysaccharide Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways			PPARA activates gene expression VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Diacerein Rhein
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Febrile seizures (MMR vaccine-related) ( 25344690) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Blood glucose levels ( 31928498) Creatinine levels ( 29403010) Feeling miserable ( 29500382) Glycated hemoglobin levels ( 34059833) HDL cholesterol ( 20686565 19060910) Hypertension ( 31879980) Intraocular pressure ( 29785010) Lymphocyte percentage of white cells ( 27863252) Metabolic syndrome ( 22399527) Monocyte percentage of white cells ( 27863252) Mood instability ( 31168069) Neurociticism ( 29500382) Neuroticism ( 29255261) Refractive error ( 32231278) Systolic blood pressure ( 31928498) Triglyceride levels ( 32154731) Triglycerides ( 30275531)
Interacting Genes		90 interacting genes: ABI2 AKAP8L ANAPC11 AP1B1 AP2B1 APP BAG4 C1QTNF2 CADPS CCDC184 CCDC33 CCDC85B CEACAM6 CIMIP2B CYSRT1 DDI1 DHX15 DISC1 ECM1 EFS FTO GOLGA2 GOLGA6L9 GPRASP3 GRB2 HNRNPH1 HOMEZ HSF2BP HYI INKA1 INSC KANK2 KATNBL1 KCTD9 KRT75 KRTAP10-8 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP19-6 LDOC1 LIG4 LZTS2 MAGED1 MAGOHB MDFI MEOX1 MEOX2 METTL27 METTL6 MID2 MORN3 NADSYN1 NFKBID NR1H3 NUTM1 OIP5 PATZ1 PAX6 PBX4 PFDN5 PLAAT1 PNMA1 PPARA PPP4C PRDM6 PTH1R RIMBP3C RTL8C SORBS3 SPATA2 STMN3 STX5 TEPSIN TFCP2 TLE5 TRAF2 TRAPPC2L TRIM23 TRIM27 TSC1 TTC19 TTC23 VBP1 VHL ZBTB16 ZBTB8OS ZMAT5 ZNF688 ZRANB1	35 interacting genes: ACTN1 APP BAG3 CEP350 EDF1 FOXO3 GPANK1 ING3 KAT2B KDM1A LZTR1 MDFI MSTO1 NCOA1 NCOA3 NCOA6 NCOR1 NR0B2 NR3C1 NRIP1 PPARA PPARD PPARG PSMC5 RARA RXRA RXRB RXRG SIRT1 SS18L1 SUV39H1 SYT1 TMEM161A UBE2I ZXDC
Entrez ID		7918	10062
HPRD ID		00810	07211
Ensembl ID		ENSG00000204438	ENSG00000025434
Uniprot IDs		A0A024RCU2 A0A0G2JHL1 A0A1U9X7R4 B2RA66 O95872	B4DXU5 B5MBY7 F1D8N1 Q13133
PDB IDs			1UHL 3IPQ 3IPS 3IPU 5AVI 5AVL 5HJS
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Supramolecular Fiber Organization Asymmetric Cell Division	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Receptor Activity Hormone-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Positive Regulation Of Biosynthetic Process Chromatin Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Metabolic Process Transcription Coactivator Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of MiRNA Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Retinoid X Receptor Binding Nucleoplasm RNA Polymerase II Transcription Regulator Complex Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor Binding Retinoic Acid-responsive Element Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nuclear Steroid Receptor Activity Regulation Of Programmed Cell Death Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Regulation Of Lipid Metabolic Process Nucleus MRNA Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process
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