GPANK1 and FTO

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPANK1	FTO
Description		G-patch domain and ankyrin repeats 1	FTO alpha-ketoglutarate dependent dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Nucleic Acid Binding Protein Binding	Protein Binding Ferrous Iron Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Transferase Activity Oxidative RNA Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity MRNA N6-methyladenosine Dioxygenase Activity TRNA Demethylase Activity
	Biological Process		Temperature Homeostasis DNA Alkylation Repair Regulation Of Lipid Storage SnRNA Processing Regulation Of Multicellular Organism Growth RNA Repair Regulation Of Respiratory System Process Adipose Tissue Development MRNA Destabilization Regulation Of White Fat Cell Proliferation Regulation Of Brown Fat Cell Differentiation
Pathways			Reversal of alkylation damage by DNA dioxygenases
Drugs			Artenimol
Diseases			Growth retardation, developmental delay, coarse facies, and early death Type II diabetes mellitus
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Febrile seizures (MMR vaccine-related) ( 25344690) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Ulcerative colitis ( 28067908)	Adiposity ( 21706003) Adolescent idiopathic scoliosis ( 31417091) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Appendicular lean mass ( 33097823) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Beef consumption ( 32066663) Biomedical quantitative traits ( 19396169) Blood glucose levels ( 31928498) Blood urea nitrogen levels ( 29403010 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 7 years old ( 31575865) BMI at 8 years old ( 31575865) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body fat percentage ( 26833246 28270201 31453325) Body fat percentage variance ( 31453325) Body mass in chronic obstructive pulmonary disease ( 21037115) Body mass index ( 17434869 18454148 19079260 19079261 20935630 22982992 23563607 23583978 23669352 24064335 24348519 24861553 25673413 25953783 26426971 26961502 28270201 28448500 28552196 28892062 29381148 30045251 31453325 31513605 31888951) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 23535729 23535733 27117709 29059683) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast size ( 27182965) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from tea ( 33287642) Childhood body mass index ( 26604143 33045005) Chromosomal aberration frequency (chromosome type) ( 31586183) Chronotype ( 30696823) circulating leptin levels ( 26833098 32917775) Coffee consumption ( 31046077) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Dietary macronutrient intake ( 23636237 29988085) End-stage kidney disease ( 31178898) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Glycated hemoglobin levels ( 28898252) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 28869591 30598549) Height adjusted BMI ( 25044758) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference ( 25673412 28552196 31453325) Hip circumference variance ( 31453325) Intake of total sugars ( 31005972) LDL cholesterol levels ( 32203549) Lean body mass ( 28552196 28724990) Liver enzyme levels (alanine transaminase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) in asthma ( 32989782) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Melanoma ( 23455637 28212542) Menarche (age at onset) ( 21102462 25231870 27182965) Metabolic syndrome ( 22399527 31589552) Morning person ( 30696823) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-oily fish consumption ( 32066663) Nonalcoholic fatty liver disease ( 34841290) Number of sexual partners ( 30643258) Obese vs. thin ( 30677029) Obesity ( 19151714 21544081 21552555 23563607) Obesity (early onset extreme) ( 18159244 20421936 23563609) Obesity (extreme) ( 19553259 30677029 31852448) Obesity-related traits ( 17658951) Obstructive sleep apnea ( 33243845) Oily fish consumption ( 32066663) Opioid dependence (time to event) ( 34124712) Osteoarthritis ( 22763110) Pork consumption ( 32066663) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Pure non-grapefruit juice consumption ( 31046077) Red cell distribution width ( 28957414) Red vs. brown/black hair color ( 30531825) Relative sugar intake ( 32393786) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Sasang constitutional medicine type (So-Eum) ( 25888059) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Sex hormone-binding globulin levels ( 22675492) Sleep duration (long sleep) ( 30846698) Strenuous sports or other exercises ( 29899525) Subcutaneous adipose tissue ( 22589738 27918534) Subscapular skin fold thickness ( 31513605) Sugar-sweetened beverage consumption ( 31046077) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 31928498) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924) Triglyceride levels ( 28334899 32902719) Triglycerides ( 24097068 30275531) Trunk fat mass ( 28552196) Type 2 diabetes ( 17463248 17463249 17554300 18372903 19056611 20581827 22693455 22885922 23209189 24509480 26818947 26961502 28869590 30054458 30297969 30718926 32499647) Type 2 diabetes nephropathy ( 30566433) Type 2 diabetes nephropathy including microalbuminuria ( 30566433) Urate levels ( 31578528) Urinary sodium excretion ( 31409800) Urolithiasis ( 30975718) Waist circumference ( 19557197 25673412 28552196 31453325 31928498) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412 28552196) Walking pace ( 33128006) Weight ( 19079260 28552196)
Interacting Genes		90 interacting genes: ABI2 AKAP8L ANAPC11 AP1B1 AP2B1 APP BAG4 C1QTNF2 CADPS CCDC184 CCDC33 CCDC85B CEACAM6 CIMIP2B CYSRT1 DDI1 DHX15 DISC1 ECM1 EFS FTO GOLGA2 GOLGA6L9 GPRASP3 GRB2 HNRNPH1 HOMEZ HSF2BP HYI INKA1 INSC KANK2 KATNBL1 KCTD9 KRT75 KRTAP10-8 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP19-6 LDOC1 LIG4 LZTS2 MAGED1 MAGOHB MDFI MEOX1 MEOX2 METTL27 METTL6 MID2 MORN3 NADSYN1 NFKBID NR1H3 NUTM1 OIP5 PATZ1 PAX6 PBX4 PFDN5 PLAAT1 PNMA1 PPARA PPP4C PRDM6 PTH1R RIMBP3C RTL8C SORBS3 SPATA2 STMN3 STX5 TEPSIN TFCP2 TLE5 TRAF2 TRAPPC2L TRIM23 TRIM27 TSC1 TTC19 TTC23 VBP1 VHL ZBTB16 ZBTB8OS ZMAT5 ZNF688 ZRANB1	20 interacting genes: AIRIM ANKRD11 CCDC57 CLP1 DTX2 EFEMP2 GNG13 GPANK1 IL16 KLHL38 MAD2L2 MORN3 NXF1 OGT PRDM6 SHC3 TNPO2 TTC19 USP20 ZNF77
Entrez ID		7918	79068
HPRD ID		00810	19057
Ensembl ID		ENSG00000204438	ENSG00000140718
Uniprot IDs		A0A024RCU2 A0A0G2JHL1 A0A1U9X7R4 B2RA66 O95872	A0A1B0GTC5 B3KU60 Q99770 Q9C0B1
PDB IDs			3LFM 4CXW 4CXX 4CXY 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7 4QHO 4QKN 4ZS2 4ZS3 5DAB 5F8P 5ZMD 6AEJ 6AK4 6AKW 7CKK 7E8Z 7WCV 8IT9 9KNI
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Regulation Of Supramolecular Fiber Organization Asymmetric Cell Division
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