LENG1 and PRPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LENG1	PRPH
Description		leukocyte receptor cluster member 1	peripherin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Membrane Axon Cell Projection Perikaryon Type III Intermediate Filament Extracellular Exosome
	Molecular Function	Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process		Intermediate Filament Organization
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Pre-treatment viral load in HIV-1 infection ( 31219150)	Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)
Interacting Genes		90 interacting genes: ABI2 APP ASB12 BANP BEGAIN C14orf119 CALCOCO2 CARD10 CARD9 CBY2 CCDC102B CCDC136 CCDC57 CCHCR1 CDR2 CDR2L CEP55 CEP57L1 CEP70 CPSF7 DDIT4L DES DISC1 EVI5 EXOSC8 FSD2 GFAP GOLGA2 GOLGA6L9 HOMEZ HOOK1 HOOK2 IKZF3 ISY1-RAB43 KANK2 KASH5 KIFC3 KLF10 KRT19 KRT31 KRT35 KRT40 KRTAP10-8 LARP4 LDOC1 LRP2BP LZTS1 MAB21L3 MAD1L1 MEIS3 MID2 MIPOL1 MRPL28 MTUS2 NAB2 NAGK NECAB2 NTAQ1 NUTF2 OIP5 OSGEP PAK5 PDE4DIP PNMA1 PRKAR1B PRPH PSMB1 RABEP1 REL ROPN1 SCYL1 SPATA2 STX11 TCF4 TEPSIN TEX12 TFIP11 TMEM239 TRAF2 TRIB3 TRIM23 TRIM27 TRIM54 TSC1 UBL5 UBXN11 USHBP1 USO1 ZMYND12 ZRANB1	34 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT20 KRT24 KRT27 KRT31 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572
Entrez ID		79165	5630
HPRD ID		13985	01365
Ensembl ID		ENSG00000105617	ENSG00000135406
Uniprot IDs		Q96BZ8	B3KWQ6 P41219
PDB IDs
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Cytoskeleton Protein Binding Intermediate Filament Organization Supramolecular Fiber Organization Cytoplasm Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Centrosome Microtubule Binding Organelle Organization Microtubule Keratin Filament Regulation Of Autophagy Response To Muramyl Dipeptide Structural Constituent Of Cytoskeleton Microtubule-based Process Structural Constituent Of Skin Epidermis CBM Complex FHF Complex	Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Structural Constituent Of Skin Epidermis Structural Constituent Of Cytoskeleton Keratin Filament Supramolecular Fiber Organization Structural Molecule Activity Morphogenesis Of An Epithelium Tissue Morphogenesis Cytoskeleton Organization Epithelial Cell Differentiation Keratin Filament Binding Cytoskeleton Extracellular Exosome Intermediate Filament Cytoskeleton Epidermis Development Protein Binding Organelle Organization Hair Cycle Scaffold Protein Binding Cytoplasmic Stress Granule Nuclear Envelope Organization
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