MBOAT7 and UNC93B1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		MBOAT7	UNC93B1
Description		membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7	unc-93B1 regulator of TLR signaling
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Vesicle Early Phagosome Phagocytic Vesicle
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity Lysophospholipid Acyltransferase Activity	Protein Binding Toll-like Receptor Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phospholipid Biosynthetic Process Ventricular System Development Layer Formation In Cerebral Cortex Lipid Modification Phosphatidylinositol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylinositol Metabolic Process Regulation Of Triglyceride Metabolic Process	Cell Morphogenesis Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process T Cell Antigen Processing And Presentation Intracellular Protein Transport Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways		Acyl chain remodelling of PI	Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS		Cirrhosis (alcohol related) ( 26482880 32853455) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748)	Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		8 interacting genes: ADRA1A BDKRB1 FNDC3B MAPK6 SHANK3 STING1 UBC UNC93B1	31 interacting genes: AQP6 BEST2 CCDC107 CD79A CFTR CLDN7 CLPTM1 CREB3L1 CYB5R3 EBP ERGIC3 FATE1 FFAR3 FKBP7 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35H1 SSMEM1 SYNDIG1 TM4SF18 TMEM237
Entrez ID		79143	81622
HPRD ID		06925	12191
Ensembl ID		ENSG00000125505	ENSG00000110057
Uniprot IDs		Q96N66	Q9H1C4
PDB IDs		8ERC	7C76 7CYN
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Intracellular Signal Transduction Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure MAPK Cascade Bradykinin Receptor Activity Regulation Of Dendritic Spine Development Septin Cytoskeleton Positive Regulation Of Dendritic Spine Development Cytoplasmic Pattern Recognition Receptor Signaling Pathway Guanylate Kinase-associated Protein Clustering Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Neuron-glial Cell Signaling Positive Regulation Of Synaptic Transmission T Cell Antigen Processing And Presentation Toll-like Receptor 7 Signaling Pathway Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Cardiac Muscle Contraction Signal Transduction Regulation Of Blood Pressure Regulation Of The Force Of Heart Contraction By Chemical Signal Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Mitochondrial Outer Membrane Innate Immune Response-activating Signaling Pathway Toll-like Receptor Binding Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Vocal Learning Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Observational Learning Proton Channel Activity Positive Regulation Of CGAS/STING Signaling Pathway	Membrane B Cell Receptor Complex Cholesterol Biosynthetic Process Sterol Biosynthetic Process Protein Binding Endoplasmic Reticulum Membrane Steroid Biosynthetic Process Receptor Complex
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