MBOAT7 and TMEM173

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		MBOAT7	TMEM173
Gene Name		membrane bound O-acyltransferase domain containing 7	transmembrane protein 173
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Mitochondrial Outer Membrane Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Lysophospholipid Acyltransferase Activity	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Phospholipid Metabolic Process Ventricular System Development Layer Formation In Cerebral Cortex Phosphatidylinositol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Positive Regulation Of Transcription Factor Import Into Nucleus Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Cellular Response To Exogenous DsRNA
Pathways		Metabolism of lipids and lipoproteins Acyl chain remodelling of PI Phospholipid metabolism Glycerophospholipid biosynthesis	Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN STAT6-mediated induction of chemokines Innate Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Protein-Protein Interactions		3 interactors: MAPK6 TMEM173 UNC93B1	9 interactors: CCDC47 DDOST IRAK1 LTN1 MBOAT7 SGPL1 STT3A SURF4 TRIM32
Entrez ID		79143	340061
HPRD ID		06925	14173
Ensembl ID		ENSG00000125505
Uniprot IDs		Q96N66	Q86WV6
PDB IDs			4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI
Enriched GO Terms of Interacting Partners?		Activation Of Innate Immune Response Defense Response To Virus Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Toll-like Receptor 7 Signaling Pathway Response To Virus Interferon-beta Production Cellular Response To Exogenous DsRNA Positive Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Interferon-beta Type I Interferon Production Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Immune Response Regulation Of Protein Import Into Nucleus, Translocation Response To Interferon-beta Response To Other Organism Response To Biotic Stimulus Innate Immune Response Regulation Of Defense Response To Virus By Host Regulation Of Immune Response Positive Regulation Of Immune System Process Cellular Response To DsRNA Positive Regulation Of Transcription Factor Import Into Nucleus Response To Exogenous DsRNA Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Protein Binding Immune Response Regulation Of Immune System Process Defense Response Response To DsRNA Positive Regulation Of Type I Interferon Production Regulation Of Defense Response To Virus Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Binding Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To External Stimulus Cytokine Production
Tagcloud ?			advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Difference) ?			advantage antibacterial autophagic autophagosome autophagy causative colocalizes connected cytosolic defense dram1 flux immunity marinum modulator mycobacterium myd88 nfkb p62 pathogen protects sensor sqstm1 sting summarize tlr toll took zebrafish
Tagcloud (Intersection) ?