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ALG8 and RPS6KA5
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
ALG8
RPS6KA5
Gene Name
ALG8, alpha-1,3-glucosyltransferase
ribosomal protein S6 kinase, 90kDa, polypeptide 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Alpha-1,3-mannosyltransferase Activity
Dolichyl Pyrophosphate Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Protein N-linked Glycosylation
Dolichol-linked Oligosaccharide Biosynthetic Process
Oligosaccharide-lipid Intermediate Biosynthetic Process
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Mannosylation
Negative Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Inflammatory Response
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Histone Phosphorylation
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Histone Phosphorylation
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Positive Regulation Of Histone Acetylation
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Histone H3-S10 Phosphorylation
Histone H3-S28 Phosphorylation
Histone H2A-S1 Phosphorylation
Innate Immune Response
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Pathways
Defective ALG2 causes ALG2-CDG (CDG-1i)
Diseases of glycosylation
Defective ALG3 causes ALG3-CDG (CDG-1d)
Post-translational protein modification
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective MOGS causes MOGS-CDG (CDG-2b)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Defective ALG11 causes ALG11-CDG (CDG-1p)
Diseases associated with N-glycosylation of proteins
CREB phosphorylation
Axon guidance
Toll Like Receptor 7/8 (TLR7/8) Cascade
CREB phosphorylation
L1CAM interactions
Recycling pathway of L1
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
NCAM signaling for neurite out-growth
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Innate Immune System
Signalling by NGF
MAP kinase activation in TLR cascade
TRIF-mediated TLR3/TLR4 signaling
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 4 (TLR4) Cascade
ERK/MAPK targets
Toll Like Receptor 3 (TLR3) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Bone mineral density (
22504420
)
Protein-Protein Interactions
2 interactors:
NAE1
RPS6KA5
59 interactors:
ACTG1
AKT1S1
ALG8
APP
ATF1
ATF2
BAD
CEBPB
CREB1
CREBBP
CRMP1
CSNK2B
DDAH2
DNAJC11
EIF4E
EIF4EBP1
EP300
ERH
ETV1
EZH2
FN1
GPRASP2
HIST1H1B
HIST1H3E
HIST2H2BE
HIST2H3C
HIST2H4A
HIST3H2A
HIST3H2BB
HIST3H3
HIST4H4
HMGN1
HSPB1
HSPB2
IL17RB
ITSN1
MAPK11
MAPK14
MAPT
MBP
MDFIC
NR4A1
PDLIM1
PLA2G4A
RAI1
RELA
RNF19A
ROBO2
RPA1
SMAD6
SMARCB1
STAT1
STAT3
STK11
TH
TXNDC11
UNC119
ZAK
ZNF775
Entrez ID
79053
9252
HPRD ID
10480
06789
Ensembl ID
ENSG00000159063
ENSG00000100784
Uniprot IDs
Q9BVK2
B7Z2Y5
O75582
Q9UG98
PDB IDs
1VZO
3KN5
3KN6
Enriched GO Terms of Interacting Partners
?
Histone H2A-S1 Phosphorylation
Histone H3-S10 Phosphorylation
Mitotic DNA Replication Checkpoint
Positive Regulation Of Histone Phosphorylation
Histone H3-S28 Phosphorylation
Protein Neddylation
DNA Replication Checkpoint
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Interleukin-1-mediated Signaling Pathway
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Histone Acetylation
Histone-serine Phosphorylation
Positive Regulation Of Peptidyl-lysine Acetylation
Positive Regulation Of Protein Acetylation
Histone Phosphorylation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Histone Acetylation
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Cellular Response To Interleukin-1
Neuron Apoptotic Process
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Neuron Death
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Histone Modification
Toll-like Receptor 4 Signaling Pathway
Response To Interleukin-1
Mitotic DNA Integrity Checkpoint
Toll-like Receptor Signaling Pathway
Stress-activated MAPK Cascade
Peptidyl-serine Phosphorylation
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Histone Modification
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Metabolic Process
Defense Response
Enzyme Linked Receptor Protein Signaling Pathway
Response To Abiotic Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Cellular Response To Organic Substance
Cellular Response To Stress
Neurotrophin Signaling Pathway
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Cell Differentiation
Innate Immune Response
Immune Response
Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
System Development
Regulation Of Cell Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Developmental Process
Nucleobase-containing Compound Metabolic Process
Nitrogen Compound Metabolic Process
Anatomical Structure Development
Response To Hormone
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Multicellular Organismal Development
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Immune System Process
Chromatin Organization
Chromosome Organization
Generation Of Neurons
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Immune Response-regulating Signaling Pathway
Stress-activated MAPK Cascade
MyD88-independent Toll-like Receptor Signaling Pathway
Tagcloud
?
27a
5p
arrays
bioinformatics
cbl
changed
creb
creb1
directive
erk2
escc
esophageal
folds
grb2
mapk1
mapk14
microrna
mir
mirna
mirnas
ngfr
options
prediction
pt1n0
sos1
sprouty
spry2
taqman
verify
Tagcloud (Difference)
?
27a
5p
arrays
bioinformatics
cbl
changed
creb
creb1
directive
erk2
escc
esophageal
folds
grb2
mapk1
mapk14
microrna
mir
mirna
mirnas
ngfr
options
prediction
pt1n0
sos1
sprouty
spry2
taqman
verify
Tagcloud (Intersection)
?