ALG8 and NAE1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ALG8	NAE1
Description		ALG8 alpha-1,3-glucosyltransferase	NEDD8 activating enzyme E1 subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Cytoplasm Cytosol Plasma Membrane Membrane Protein-containing Complex Glutamatergic Synapse
	Molecular Function	Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity	Protein Binding Ubiquitin-like Modifier Activating Enzyme Activity NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine	Apoptotic Process Signal Transduction Mitotic DNA Replication Checkpoint Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process Regulation Of Postsynapse Assembly
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG8 causes CDG-1h	Neddylation
Drugs			ATP
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Depression in smokers ( 30219690) Femur bone mineral density x serum urate levels interaction ( 34046847) Tourette syndrome ( 30818990)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)
Interacting Genes		12 interacting genes: BIK CLRN1 CREB3 CREB3L1 CYB5R3 FAM209A GPX8 LMNA MFSD6 NAE1 RPS6KA5 SAR1A	12 interacting genes: ALG8 APP CEBPA GARS1 NEDD8 OGT SREBF2 TP53BP2 TRIP12 UBA3 UBE2F UBQLN4
Entrez ID		79053	8883
HPRD ID		10480	04545
Ensembl ID		ENSG00000159063	ENSG00000159593
Uniprot IDs		A0A024R5K5 A0A7P0TA89 A0A7P0TAA8 A0A7P0Z449 A0A804G6E3 E9PR58 H0YCV0 H0YD42 H0YDD3 H0YEE0 Q9BVK2	Q13564
PDB IDs			1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?			Protein Neddylation Regulation Of Proteolysis NEDD8 Transferase Activity Protein Metabolic Process Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Protein-containing Complex Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Regulation Of Synapse Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytosol Identical Protein Binding Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glycyl-tRNA Aminoacylation Mitochondrial Glycyl-tRNA Aminoacylation Glycine-tRNA Ligase Activity ATP:ATP Adenylyltransferase Activity Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Dolichyl-phosphate-glucose-glycolipid Alpha-glucosyltransferase Activity Dolichyl Pyrophosphate Glc1Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity Regulation Of Cell Junction Assembly Regulation Of Carbohydrate Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Acetylcholine Receptor Activator Activity Regulation Of ATP Metabolic Process Regulation Of Synapse Organization Regulation Of MiRNA Transcription Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Diadenosine Tetraphosphate Biosynthetic Process C-8 Sterol Isomerase Activity NEDD8 Activating Enzyme Activity
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