ALG8

Gene Name		ALG8, alpha-1,3-glucosyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Alpha-1,3-mannosyltransferase Activity Dolichyl Pyrophosphate Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Mannosylation
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: NAE1 RPS6KA5
Entrez ID		79053
HPRD ID		10480
Ensembl ID		ENSG00000159063
Uniprot IDs		Q9BVK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone H2A-S1 Phosphorylation Histone H3-S10 Phosphorylation Mitotic DNA Replication Checkpoint Positive Regulation Of Histone Phosphorylation Histone H3-S28 Phosphorylation Protein Neddylation DNA Replication Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Interleukin-1-mediated Signaling Pathway Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Acetylation Histone-serine Phosphorylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Histone Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Histone Acetylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 Neuron Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neuron Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Histone Modification Toll-like Receptor 4 Signaling Pathway Response To Interleukin-1 Mitotic DNA Integrity Checkpoint Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Histone Modification Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Phase Transition
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