RPN1 and ADRM1

Number of citations of the paper that reports this interaction (PMID 16990800)
58

Data Source:
HPRD (in vitro)

		RPN1	ADRM1
Gene Name		ribophorin I	adhesion regulating molecule 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome	Proteasome Complex Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Poly(A) RNA Binding	Protease Binding Protein Binding Endopeptidase Activator Activity Proteasome Binding
	Biological Process	Translation Cellular Protein Modification Process SRP-dependent Cotranslational Protein Targeting To Membrane Gene Expression Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Endopeptidase Activity Proteasome Assembly
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Translation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification SRP-dependent cotranslational protein targeting to membrane Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS		Monocyte count ( 23314186) White blood cell count ( 21738480)	Prostate cancer ( 23535732)
Protein-Protein Interactions		13 interactors: ADRM1 ASB11 DPF1 ERBB3 HSPA5 RAD23A RBBP4 SGTA SIGIRR UBQLN1 UBQLN2 UBQLN4 WSB2	16 interactors: APP ATP6V0D2 DDI1 EGFR PSMD1 PSMD14 PSMD2 PSMD4 RAD23A RAD23B RPN1 RPN2 UBE3A UBQLN1 UBQLN2 UCHL5
Entrez ID		6184	11047
HPRD ID		01598	06440
Ensembl ID		ENSG00000163902	ENSG00000130706
Uniprot IDs		P04843	Q16186
PDB IDs			2KQZ 2KR0 2L5V
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization	Regulation Of Protein Catabolic Process Regulation Of Proteolysis Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Cellular Macromolecule Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle G1/S Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Protein Polyubiquitination Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteolysis Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Amino Acid Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Ligase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Ubiquitin-protein Transferase Activity Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Cellular Ketone Metabolic Process Cellular Protein Metabolic Process Regulation Of Cell Cycle Arrest Protein Metabolic Process Mitotic Cell Cycle Phase Transition
Tagcloud ?		26s adopts atp atph coexisting commitment conformational conformations cryo dataset deconvolutes deubiquitylation em ensemble essentially executes gammas hydrolyzing interpretable landscape lid machine module move polyubiquitylated proteasome rendered static topology	bassoon carbohydrate deficits enables glcnac glcnacation implication interplay isotopic itraq lectin ltq mapped mek2 overlap p25 piccolo plasticity polymerization pqd proteasomal proteomics pulsed quantitation rpn13 synapses synapsin synaptic tubulin
Tagcloud (Difference) ?		26s adopts atp atph coexisting commitment conformational conformations cryo dataset deconvolutes deubiquitylation em ensemble essentially executes gammas hydrolyzing interpretable landscape lid machine module move polyubiquitylated proteasome rendered static topology	bassoon carbohydrate deficits enables glcnac glcnacation implication interplay isotopic itraq lectin ltq mapped mek2 overlap p25 piccolo plasticity polymerization pqd proteasomal proteomics pulsed quantitation rpn13 synapses synapsin synaptic tubulin
Tagcloud (Intersection) ?