CACNB2 and NRP1

		CACNB2	NRP1
Description		calcium voltage-gated channel auxiliary subunit beta 2	neuropilin 1
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Sarcolemma Photoreceptor Ribbon Synapse Presynapse L-type Voltage-gated Calcium Channel Complex	Semaphorin Receptor Complex Extracellular Region Extracellular Space Cytoplasm Mitochondrion Early Endosome Cytosol Neurofilament Plasma Membrane Focal Adhesion Membrane Axon Cytoplasmic Vesicle Mitochondrial Membrane Neuron Projection Receptor Complex Postsynaptic Membrane Sorting Endosome Glutamatergic Synapse
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Actin Filament Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels	Vascular Endothelial Growth Factor Receptor Activity GTPase Activator Activity Protein Binding Heparin Binding Coreceptor Activity Semaphorin Receptor Activity Growth Factor Binding Protein Kinase Binding Cytokine Binding Vascular Endothelial Growth Factor Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Neuromuscular Junction Development Visual Perception Monoatomic Ion Transmembrane Transport Positive Regulation Of Muscle Contraction Positive Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Depolarization During AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Neural Crest Cell Migration Neuron Migration Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Integrin-mediated Signaling Pathway Cell-cell Signaling Nervous System Development Axon Guidance Axonal Fasciculation Heart Development Motor Neuron Axon Guidance Response To Wounding Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Smooth Muscle Cell Migration Dendrite Development Facial Nerve Structural Organization Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vestibulocochlear Nerve Structural Organization Branchiomotor Neuron Axon Guidance Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Cell Differentiation Negative Regulation Of Axon Extension Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Regulation Of Cdc42 Protein Signal Transduction Cellular Response To Hepatocyte Growth Factor Stimulus Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Ventral Trunk Neural Crest Cell Migration Vascular Endothelial Growth Factor Signaling Pathway Neuropilin Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Endothelial Cell Migration Positive Regulation Of Angiogenesis Symbiont Entry Into Host Cell Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Sympathetic Nervous System Development Neuron Development Axon Extension Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Axon Extension Involved In Axon Guidance Positive Chemotaxis Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Axonogenesis Involved In Innervation Regulation Of Vesicle-mediated Transport Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Retina Vasculature Development In Camera-type Eye Retina Vasculature Morphogenesis In Camera-type Eye Renal Artery Morphogenesis Sympathetic Ganglion Development Trigeminal Ganglion Development Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Commissural Neuron Axon Guidance Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tip Cell Fate Specification Sensory Neuron Axon Guidance Motor Neuron Migration Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Postsynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Basal Dendrite Development Basal Dendrite Arborization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neural Crest Cell Migration Involved In Autonomic Nervous System Development Protein Localization To Early Endosome Facioacoustic Ganglion Development Dorsal Root Ganglion Morphogenesis Otic Placode Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase Sensory processing of sound by inner hair cells of the cochlea Mechanical load activates signaling by PIEZO1 and integrins in osteocytes	Neurophilin interactions with VEGF and VEGFR Signaling by ROBO receptors Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Signal transduction by L1 CHL1 interactions Attachment and Entry
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Nicardipine Nicardipine Magnesium sulfate Verapamil Levomenthol Felodipine Nitrendipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Nilvadipine Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases		Brugada syndrome (BRS)
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 34002096) Blood pressure ( 21909110) Body mass index ( 28892062) Brain volume in infants (grey matter) ( 28763065) Cadmium levels ( 26025379) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 21909115 28739976 27841878 27618452 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertension ( 31879980 19430479 21909115) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (HVA/MHPG ratio) ( 23319000) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Quantitative traits ( 19197348) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Schizophrenia ( 30285260 23974872 29483656 25056061 28991256) Small vessel stroke ( 26732560) Systolic blood pressure ( 21909115 27618452 27841878 19430479 28135244 28739976 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White matter hyperintensity volume ( 33293549)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Migraine ( 27322543) Reticulocyte count ( 32888494) Schizophrenia ( 21682944) Small cell lung carcinoma ( 28604730) Tetralogy of Fallot ( 23297363) Type 1 diabetes ( 34127860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CTBP2 HEXIM2 PRKACA PRMT5 REM1 TMEM174	27 interacting genes: FGF1 FGF2 FGF4 FGF7 FGFR1 FLT1 GIPC1 KDR L1CAM NRP2 PGF PLXNA1 PLXNB1 RPL27 SEMA3A SEMA3B SEMA3C SEMA3F SNCA SNX5 SNX6 TGFBR1 TGFBR2 TGFBR3 USP9X VEGFA VEGFB
Entrez ID		783	8829
HPRD ID		02473	03642
Ensembl ID		ENSG00000165995	ENSG00000099250
Uniprot IDs		A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1	A8K9V7 E9PEP6 O14786 Q59F20 Q6X907
PDB IDs		8HLP 8HMA 8HMB	1KEX 2QQI 2QQM 2QQN 3I97 4DEQ 4RN5 5C7G 5IJR 5IYY 5J1X 5JGI 5JGQ 5JHK 5L73 6FMC 6FMF 6TKK 7JJC 7O1N 7P5U 8C5G 8PFE 9EOU
Enriched GO Terms of Interacting Partners?			Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Semaphorin-plexin Signaling Pathway Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Heparin Binding Chemotaxis Cell Motility Cell Surface Receptor Signaling Pathway Locomotion Vascular Endothelial Growth Factor Signaling Pathway Tissue Morphogenesis Positive Regulation Of Cell Division Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Regulation Of Chemotaxis Neuropilin Binding Angiogenesis Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Region Positive Regulation Of Cell Population Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Semaphorin Receptor Binding Lung Development Anatomical Structure Morphogenesis Regulation Of Cell Division Positive Regulation Of Vasculature Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelial Cell Migration Regulation Of Endothelial Cell Migration Positive Regulation Of Phosphate Metabolic Process Chemoattractant Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Growth Factor Developmental Growth Involved In Morphogenesis Neuron Projection Guidance Positive Regulation Of MAPK Cascade Morphogenesis Of An Epithelium Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus
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