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CACNB2
Gene Name
calcium channel, voltage-dependent, beta 2 subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Integral Component Of Plasma Membrane
Voltage-gated Calcium Channel Complex
Sarcolemma
Molecular Function
Voltage-gated Calcium Channel Activity
Calcium Channel Activity
Protein Binding
High Voltage-gated Calcium Channel Activity
Biological Process
Transport
Synaptic Transmission
Axon Guidance
Neuromuscular Junction Development
Visual Perception
Positive Regulation Of Calcium Ion Transport
Calcium Ion Import
Calcium Ion Transmembrane Transport
Regulation Of Voltage-gated Calcium Channel Activity
Pathways
NCAM1 interactions
Axon guidance
Integration of energy metabolism
Regulation of insulin secretion
NCAM signaling for neurite out-growth
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
Transmission across Chemical Synapses
Adrenaline,noradrenaline inhibits insulin secretion
Drugs
Diseases
GWAS
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) (
23453885
)
Blood pressure (
21909110
)
Diastolic blood pressure (
19430479
21909115
)
Hypertension (
19430479
21909115
)
Metabolite levels (HVA/MHPG ratio) (
23319000
)
Obesity-related traits (
23251661
)
Primary tooth development (number of teeth) (
23704328
)
Primary tooth development (time to first tooth eruption) (
23704328
)
Protein quantitative trait loci (
18464913
)
Quantitative traits (
19197348
)
Systolic blood pressure (
19430479
21909115
)
Protein-protein Interactions
2 interactors:
PRKACA
REM1
Entrez ID
783
HPRD ID
02473
Ensembl ID
ENSG00000165995
Uniprot IDs
A6PVM6
Q08289
Q59H42
Q5QJ99
Q5VVH1
Q6TME3
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Dense Core Granule Biogenesis
Histone H3-T6 Phosphorylation
Peptidyl-serine Autophosphorylation
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Cellular Response To Parathyroid Hormone Stimulus
Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Desmosome Assembly
Negative Regulation Of Glial Cell Apoptotic Process
Regulation Of Tight Junction Assembly
Negative Regulation Of Glucose Import
Positive Regulation Of Macrophage Differentiation
Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Response To Parathyroid Hormone
Calcium-mediated Signaling Using Intracellular Calcium Source
Desmosome Organization
Positive Regulation Of Protein Export From Nucleus
Cell Communication By Electrical Coupling
Activation Of Protein Kinase A Activity
Regulation Of Platelet Aggregation
Negative Regulation Of Glucose Transport
Sperm Capacitation
Cellular Response To Epinephrine Stimulus
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Induction Of Positive Chemotaxis
Positive Regulation Of Cardiac Muscle Hypertrophy
Response To Epinephrine
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Triglyceride Catabolic Process
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Rhodopsin Mediated Signaling Pathway
Acylglycerol Catabolic Process
Cellular Response To Catecholamine Stimulus
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of CAMP Biosynthetic Process
Renal Water Homeostasis
Activation Of Adenylate Cyclase Activity
Negative Regulation Of Embryonic Development
Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Protein Export From Nucleus
Rhodopsin Mediated Signaling Pathway
Regulation Of Platelet Activation
Positive Regulation Of Positive Chemotaxis
Negative Regulation Of CAMP Metabolic Process
Regulation Of The Force Of Heart Contraction
Inactivation Of MAPK Activity
Negative Regulation Of Smoothened Signaling Pathway
Tagcloud
?
aggregated
aggregately
ancestry
atp2b1
bp
conditioning
consortium
cyp17a1
dbp
epidemiology
gwas
harbor
individually
intronic
jag1
ld
maf
plekha7
pp
rs11191416
rs112467382
rs12806040
rs1571787
rs6163
rs743572
sbp
sh2b3
snp
strongest