CACNB2

Name calcium voltage-gated channel auxiliary subunit beta 2
Structure PDB 8HLP
Novel Interactors 7 novel interactors: C10orf67 GPR85 MSRB2 NEBL NRP1 PDIA3 PTER
Interactors 6 interactors: CTBP2 HEXIM2 PRKACA PRMT5 REM1 TMEM174
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 )
  • Antisaccade task score ( 31596458 )
  • Apolipoprotein B levels ( 32203549 )
  • Autism spectrum disorder or schizophrenia ( 28540026 )
  • Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 )
  • Bipolar disorder ( 34002096 )
  • Blood pressure ( 21909110 )
  • Body mass index ( 28892062 )
  • Brain volume in infants (grey matter) ( 28763065 )
  • Cadmium levels ( 26025379 )
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 )
  • Diastolic blood pressure ( 21909115 28739976 27841878 27618452 19430479 )
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858 )
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
  • Diverticular disease ( 30177863 )
  • Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 )
  • Hypertension ( 31879980 19430479 21909115 )
  • LDL cholesterol levels ( 32203549 )
  • Mean arterial pressure ( 27618448 )
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 )
  • Medication use (agents acting on the renin-angiotensin system) ( 31015401 )
  • Medication use (beta blocking agents) ( 31015401 )
  • Medication use (calcium channel blockers) ( 31015401 )
  • Medication use (diuretics) ( 31015401 )
  • Metabolite levels (HVA/MHPG ratio) ( 23319000 )
  • Nicotine dependence symptom count ( 25555482 )
  • Obesity-related traits ( 23251661 )
  • Primary tooth development (number of teeth) ( 23704328 )
  • Primary tooth development (time to first tooth eruption) ( 23704328 )
  • Protein quantitative trait loci ( 18464913 )
  • Pulse pressure ( 30578418 )
  • Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 )
  • Quantitative traits ( 19197348 )
  • Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125 )
  • Schizophrenia ( 30285260 23974872 29483656 25056061 28991256 )
  • Small vessel stroke ( 26732560 )
  • Systolic blood pressure ( 21909115 27618452 27841878 19430479 28135244 28739976 30578418 )
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858 )
  • Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 )
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 )
  • White matter hyperintensity volume ( 33293549 )
Entrez ID 783
HPRD ID 02473
Ensembl ID ENSG00000165995
Uniprot IDs A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1
PDB IDs 8HLP 8HMA 8HMB