DAP3 and FADD

Number of citations of the paper that reports this interaction (PMID 11376335)
15

Data Source:
HPRD (in vivo, two hybrid)

		DAP3	FADD
Gene Name		death associated protein 3	Fas (TNFRSF6)-associated via death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Small Ribosomal Subunit	Cytosol Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Neuron Projection Cell Body Membrane Raft Ripoptosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protease Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Protein Complex Binding Tumor Necrosis Factor Receptor Superfamily Binding Death Effector Domain Binding Identical Protein Binding
	Biological Process	Organelle Organization Apoptotic Mitochondrial Changes Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination Apoptotic Signaling Pathway	Positive Regulation Of T Cell Mediated Cytotoxicity Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Viral Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Activated T Cell Proliferation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Spleen Development Thymus Development Protein Heterooligomerization Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Activation-induced Cell Death Of T Cells Cellular Response To Mechanical Stimulus Motor Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Necroptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Regulation by c-FLIP Caspase-8 activation by cleavage Death Receptor Signalling Dimerization of procaspase-8 TRAIL signaling TRIF-mediated TLR3/TLR4 signaling FasL/ CD95L signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Extrinsic Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AHR AR ESR1 ESR2 FADD HIF1A HSP90AA1 NR3C1 PGR PPARA THRA TNFRSF10A TNFRSF25	45 interactors: ABCA1 ANK3 ATG5 CASP10 CASP8 CASP8AP2 CFLAR CSNK1A1 DAP3 DAPK1 DDX24 DEDD EDA2R FAF1 FAS FASLG HIPK3 IKBKG IRAK1 LRRCC1 MBD4 MKRN1 MOB4 MYD88 NACA NOL3 PARK7 PEA15 PIDD1 PRKCZ PTPN13 RALBP1 RAP1A RIPK1 RYBP SPOP STAT1 SUMO1 TAB1 TNFRSF10A TNFRSF10B TRADD TRAF2 TRIM21 XPO5
Entrez ID		7818	8772
HPRD ID		03646	03909
Ensembl ID		ENSG00000132676	ENSG00000168040
Uniprot IDs		P51398	Q13158
PDB IDs			1A1W 1A1Z 1E3Y 1E41 2GF5 3EZQ 3OQ9
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Gland Development Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Lipid Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Signal Transduction Cellular Response To Hormone Stimulus Signaling Positive Regulation Of Macromolecule Biosynthetic Process Cell Communication Positive Regulation Of Gene Expression Regulation Of Cell Death Positive Regulation Of Metabolic Process Response To Organic Substance Prostate Gland Development Cellular Response To Organic Substance Cellular Response To Stimulus Reproductive Process Response To Lipid Reproductive Structure Development Response To Organic Cyclic Compound Reproductive System Development Epithelial Cell Maturation Mammary Gland Epithelium Development Regulation Of Apoptotic Process Response To Hormone Organ Development System Development Organ Morphogenesis Transcription, DNA-templated Rhythmic Process RNA Biosynthetic Process Epithelium Development TRAIL-activated Apoptotic Signaling Pathway Response To Stimulus Developmental Process Involved In Reproduction Multicellular Organismal Development Regulation Of Nitric-oxide Synthase Activity	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Peptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Zymogen Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Endopeptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Protein Processing Regulation Of Proteolysis Negative Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Activation Of Protein Kinase Activity
Tagcloud ?		biogenesis constituent coregulated ctf1 elk1 elk4 esrra exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated	adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Difference) ?		biogenesis constituent coregulated ctf1 elk1 elk4 esrra exploring gabpa gtp hdap3 homoeostasis hox11 microarray mitochondrial nrf oncocytic pparg presenting publicly ribosome runx1 rxra silico tal1 ternary tumourigenesis tumours upregulated	adaptor appear characterization convey daxx death domains effector far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd traf traf1 transmit
Tagcloud (Intersection) ?